Title:
ｍｉＲＮＡをターゲットとした神経変性疾患の治療
Document Type and Number:
Japanese Patent JP5710001
Kind Code:
B2
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating neurodegenerative diseases by targeting a specific miRNA. In addition, the present invention relates to a kit for diagnosing neurodegenerative diseases. A miR-206 target found in the present invention, which is highly expressed in both animal models of Alzheimer's disease and human brain samples, is a substantial treatment target selected without artifact errors. An antisense oligonucleotide of the present invention as an inhibitor for miR-206 suggests a successful result in treatment of neurodegenerative diseases by targeting miRNA. The antisense oligonucleotide of the present invention inhibits the function of miR-206 to greatly increase the levels of BDNF and IGF-1 and to increase the regeneration of synapses, thereby treating neurodegenerative diseases, particularly Alzheimer's disease.
Inventors:
No Jaekyu
Lee Sang Khun
Kim Man Ho
Ju Kong
Jung Gun Hwa
Lee Sun Tae
Lee Sang Khun
Kim Man Ho
Ju Kong
Jung Gun Hwa
Lee Sun Tae
Application Number:
JP2013529052A
Publication Date:
April 30, 2015
Filing Date:
September 09, 2011
Export Citation:
Assignee:
SNU R&DB FOUNDATION
International Classes:
A61K48/00; A61K31/7088; A61K31/712; A61P21/02; A61P25/28; C12Q1/68; G01N33/53
Domestic Patent References:
| JP2009519339A |
Foreign References:
| WO2009026576A1 | ||||
| WO2007044937A1 | ||||
| WO2009117418A1 | ||||
| WO2008147974A1 |
Other References:
Hugon,J. et al,Targeting miRNAs in Alzheimer’s disease,Expert Review of Neurotherapeutics,2008年,Vol. 8, No. 11,pp. 1615-1616
RAU CHENG-SHYUAN et al,Entrapment neuropathy results in different microRNA expression patterns from denervation injury in rats,BMC MUSCULOSKELETAL DISORDERS,2010年,vol. 11, no. 1,pp. 181(1-9)
RAU CHENG-SHYUAN et al,Entrapment neuropathy results in different microRNA expression patterns from denervation injury in rats,BMC MUSCULOSKELETAL DISORDERS,2010年,vol. 11, no. 1,pp. 181(1-9)
Attorney, Agent or Firm:
Koichi Hirota
Yoshihiro Nagare
Naoko Matsuda
Yoshihiro Nagare
Naoko Matsuda