Title:
ケモカイン受容体CCR5モジュレータによるストレス応答の治療
Document Type and Number:
Japanese Patent JP2005529067
Kind Code:
A
Abstract:
The use of chemokine receptor CCR5 modulators (e.g., CCR5 antagonists) is disclosed for the treatment or prevention of stress response (e.g., fever) in a subject resulting from surgery, infection or other insult to the subject (e.g., a warm-blooded vertebrate). Methods for treating or preventing disorders involving the activation of pro-inflammatory cytokines by administration of a CCR5 modulator, for inhibiting the endogenous production of pro-inflammatory cytokines by the administration of CCR5 modulators, and for determining the efficacy of CCR5 modulators in correcting abnormal levels of pro-inflammatory cytokines are also disclosed.
Inventors:
Demartino, Giully A
Pearson, Litchiard N, The Third
Azim Zado, Agnes M
Schroder, Karsten
Pearson, Litchiard N, The Third
Azim Zado, Agnes M
Schroder, Karsten
Application Number:
JP2003561603A
Publication Date:
September 29, 2005
Filing Date:
January 22, 2003
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
A61K31/445; A61K31/454; A61K38/00; A61K39/395; A61K45/00; A61P7/00; A61P7/08; A61P9/00; A61P9/02; A61P11/00; A61P17/02; A61P19/00; A61P25/04; A61P29/00; A61P31/04; A61P37/02; A61P37/06; A61P39/00; A61P41/00; A61P43/00; C07D401/04; C07D415/00; C07D471/04; C07D513/04; C07D413/04; (IPC1-7): A61K45/00; A61K31/454; A61K38/00; A61K39/395; A61P7/00; A61P7/08; A61P9/00; A61P9/02; A61P11/00; A61P17/02; A61P19/00; A61P25/04; A61P29/00; A61P31/04; A61P37/02; A61P37/06; A61P39/00; A61P41/00; A61P43/00; C07D413/04; C07D415/00; C07D471/04; C07D513/04
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura