Title:
TREATMENT FOR SUSURRUS AURIUM USING NERVE-PROTECTING AGENT
Document Type and Number:
Japanese Patent JP3038155
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a medicinal composition for treating susurrus aurium which contains a specific nerve-protecting agent as an active ingredient and can cure, relieve and prevent mammalian susurrus aurium.
SOLUTION: This susurrus aurium treatment uses a compound of formula I [when R2 and R5 are different groups from each other, R1-R4 are independently H, a 1-6C alkyl, a halo, trifluoromethyl; R5 is methyl; when R2 and R5 are incorporated to form a group of formula II forming chroman-4-ol ring, R1, R3 and R4 are independently H, a 1-6C alkyl, and a halo; R6 is a group of formula III (R8 is a 1-6C alkyl) or its pharmaceutically permissible salt as an active ingredient. (1S, 2S)-1-(4-Hydroxyphenyl)-2-(4-hydroxy-4-phenyliperi-dinl-yl)-1- propanol, its tartaric salt, methane sulfonate salt or methane sulfonic trihydrate are particularly preferred.
Inventors:
Stephen B. Sands
Application Number:
JP26234396A
Publication Date:
May 08, 2000
Filing Date:
September 12, 1996
Export Citation:
Assignee:
Pfizer Inc.
International Classes:
A61K31/40; A61K31/407; A61K31/435; A61K31/439; A61K31/443; A61K31/445; A61K31/451; A61K31/453; A61P27/16; C07D207/12; C07D405/04; C07D211/52; C07D451/02; C07D451/04; C07D451/06; (IPC1-7): A61K31/451; A61K31/407; A61K31/439; A61P27/16
Domestic Patent References:
| JP11509839A |
Attorney, Agent or Firm:
Hiroshi Kobayashi