TREATMENT OF T-CELL MEDIATED DISEASE

Title:

TREATMENT OF T-CELL MEDIATED DISEASE

Document Type and Number:

Japanese Patent JP2006017737

Kind Code:

A

Abstract:

To develop a therapeutic compound to regulate selectively an immune response, and to treat a T-cell mediated disease.

The present invention relates to the discovery that a certain adverse inflammatory response, an allergic disease, an undesirable immune response including transplant rejection and autoimmune disease, and other disease states, can be treated or prevented by regulating the coupling of the particular chemokines SLC (secondary lymphoid chemokine), and MIP-3β (macrophage inflammatory protein-3b) onto an immune system T cell and a dendritic cell. The present invention also provides a method for screening the therapeutic compound useful in the treatment of SLC mediated and MIP-3β mediated disorders, and the compound detected by such the screening. An appropriate assay is also disclosed.

Inventors:

GLADUE RONALD P
MARTIN WILLIAM HOLT
POSS CHRISTOPHER S

Application Number:

JP2005214761A

Publication Date:

January 19, 2006

Filing Date:

July 25, 2005

Export Citation:

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Assignee:

PFIZER PROD INC

International Classes:

G01N33/50; A61K31/428; A61K31/5415; A61K45/00; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P9/10; A61P9/14; A61P11/00; A61P11/02; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P21/00; A61P25/00; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/00; A61P31/06; A61P31/08; A61P31/16; A61P31/18; A61P35/00; A61P35/04; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D417/12; C07D419/12; C12Q1/02; G01N33/15; G01N33/566; G01N33/68

Attorney, Agent or Firm:

Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Osamu Yamamoto

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