Title:
ナトリウム-プロトン交換阻害剤としての三還式グアニジン誘導体
Document Type and Number:
Japanese Patent JP4921375
Kind Code:
B2
Abstract:
Guanidine derivatives having a condensed tricyclic ring of formula 1: are disclosed, wherein U is C(O), CRaRb, O, NRa or S(O)m; V is CRaRb or NRa; W is S(O)m; wherein Ra is H, alkyl, cycloalkyl, alkenyl or aralkyl; Rb is H, alkyl, OH, ORa or OCORa, and m is the integer 0, 1 or 2; R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein with the proviso that at least one of R1, R2, R3, R4, R5, R6, R7 or R8 is guanidino or guanidinocarbonyl. These derivatives are sodium-proton exchange inhibitors and are useful as medicaments for the treatment of, for example, organ disorders associated with ischemia and reperfusion, cardiac arrhythmia, cardiac hypertrophy, hypertension, cell proliferative disorders and diabetes.
Inventors:
Bansi Ral
Swati bal tenbe
Usha Gauche
Arun Kumar Jane
Tulceders More
Anil Gate
Jacqueline Trivedy
Sapna Parik
Swati bal tenbe
Usha Gauche
Arun Kumar Jane
Tulceders More
Anil Gate
Jacqueline Trivedy
Sapna Parik
Application Number:
JP2007540781A
Publication Date:
April 25, 2012
Filing Date:
November 08, 2005
Export Citation:
Assignee:
Piramal Life Sciences Limited
International Classes:
C07D281/14; A61K31/38; A61K31/39; A61K31/4025; A61K31/4178; A61K31/433; A61K31/4436; A61K31/4535; A61K31/496; A61K31/5377; A61K31/554; A61P3/10; A61P7/02; A61P9/06; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P13/12; A61P37/06; A61P43/00; C07D327/02; C07D337/12; C07D411/04; C07D411/06; C07D411/12; C07D417/12
Domestic Patent References:
| JPS57176980A | 1982-10-30 | |||
| JP2002542291A | 2002-12-10 | |||
| JPH10152481A | 1998-06-09 | |||
| JPH1081664A | 1998-03-31 | |||
| JPH09169721A | 1997-06-30 |
Foreign References:
| WO2003066620A1 | 2003-08-14 | |||
| US4431808A | 1984-02-14 |
Attorney, Agent or Firm:
Yoshiro Kurauchi