Title:
TRI-SEGMENTED ARENAVIRUSES AS VACCINE VECTORS
Document Type and Number:
Japanese Patent JP2021045154
Kind Code:
A
Abstract:
To provide tri-segmented arenaviruses for using arenavirus in vaccines and/or treatment of diseases and/or immunotherapies, which do not recombine into a replication-competent bi-segmented arenavirus particle and can be engineered to improve genetic stability and ensure lasting transgene expression.SOLUTION: There is provided a tri-segmented arenavirus particle which comprises one L segment and two S segments or two L segments and one S segment and is engineered to carry a viral ORF in a position other than the wild-type position of the ORF.SELECTED DRAWING: Figure 1
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Inventors:
DANIEL DAVID PINSCHEWER
DORON MERKLER
SANDRA MARGARETE KALLERT
MARIO KREUTZFELDT
STEPHANIE GABRIELLE DARBRE ABDELRAHMAN
NICOLAS JEAN PAGE
DORON MERKLER
SANDRA MARGARETE KALLERT
MARIO KREUTZFELDT
STEPHANIE GABRIELLE DARBRE ABDELRAHMAN
NICOLAS JEAN PAGE
Application Number:
JP2020201083A
Publication Date:
March 25, 2021
Filing Date:
December 03, 2020
Export Citation:
Assignee:
UNIV GENEVE
International Classes:
C12N15/40; A61K35/76; A61K39/00; A61K39/02; A61K39/112; A61K48/00; A61P31/14; A61P35/00; A61P37/08; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N7/01; C12N15/63
Domestic Patent References:
| JP2011507536A | 2011-03-10 |
Foreign References:
| WO2016048949A1 | 2016-03-31 |
Other References:
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J. GEN. VIROL. (2013) VOL.94, NO.16, P.1175-1188, JPN6019048312, ISSN: 0004662355
"Creation of Rift Valley Fever Viruses with Four-Segmented Genomes Reveals Flexibility in Bunyavirus", JOURNAL OF VIROLOGY, vol. Volume 88, Number 18, JPN6021049907, July 2014 (2014-07-01), pages 10883 - 10893, ISSN: 0004867696
"Coronaviruses Maintain Viability despite Dramatic Rearrangements of the Strictly Conserved Genome Or", JOURNAL OF VIROLOGY, vol. 76, no. 24, JPN6022036316, 2002, pages 12491 - 12502, ISSN: 0004867697
"Rearrangement of the Genes of Vesicular Stomatitis Virus Eliminates Clinical Disease in the Natural", JOURNAL OF VIROLOGY, vol. 75, no. 13, JPN6022036318, 2001, pages 6107 - 6114, ISSN: 0004867698
"Recombinant Respiratory Syncytial Virus with the G and F Genes Shifted to the Promoter-Proximal Posi", JOURNAL OF VIROLOGY, vol. 76, no. 23, JPN6022036317, 2002, pages 11931 - 11942, ISSN: 0004867699
"Influenza Viruses with Rearranged Genomes as Live-Attenuated Vaccines", JOURNAL OF VIROLOGY, vol. 8, no. 9, JPN6022036319, 2013, pages 5118 - 5127, ISSN: 0004867700
PROC. NATL. ACAD. SCI. U.S.A. (2009) VOL.106, NO.9, P.3473-3478, JPN6019048306, ISSN: 0004662353
J. VIROL. (2011) VOL.85, NO.15, P.7928-7932, JPN6019048310, ISSN: 0004662354
J. GEN. VIROL. (2013) VOL.94, NO.16, P.1175-1188, JPN6019048312, ISSN: 0004662355
Attorney, Agent or Firm:
Toru Ishikawa