Title:
PDE IV インヒビターとして有用なトリ置換フェニル誘導体
Document Type and Number:
Japanese Patent JP3856465
Kind Code:
B2
Abstract:
Tri-substituted phenyl derivatives and processes for their preparation. In a preferred embodiment, the compounds have the general formula (1) wherein L may be -OR; Z may be -C(R3)(R4)-C(R5)(R6)(R7); R may be an optionally substituted cycloalkyl group; R3, R6 and R7 may be hydrogen; R4 may be -(CH2)t-Ar-(L1)n-Ar'; R5 may be -(CH2)tAr; Ar may be a monocyclic or bicyclic aryl or heteroaryl group; L1 may be a divalent linking group; and Ar' is Ar or an Ar containing group. Compounds of the invention may be potent and selective phosphodiesterase type IV inhibitors and are useful in the prophylaxis and treatment of various diseases, such as asthma, which are associated with an unwanted inflammatory response or muscular spasm.
Inventors:
Valero, Graham, John
Alexander, Ricky, Peter
Alexander, Ricky, Peter
Application Number:
JP50184396A
Publication Date:
December 13, 2006
Filing Date:
June 21, 1995
Export Citation:
Assignee:
Celtec Therapeutics Limited
International Classes:
C07D213/30; A61K31/44; A61P11/06; A61P43/00; C07C1/26; C07C1/32; C07C15/02; C07C15/12; C07C17/263; C07C25/02; C07C25/18; C07C43/20; C07C57/30; C07C59/64; C07C237/04; C07C307/04; C07C311/00; C07C323/00; C07C327/00; C07C327/48; C07C335/04; C07D521/00
Domestic Patent References:
| JP8501801A |
Foreign References:
| WO1994012461A1 | ||||
| WO1994010118A1 |
Attorney, Agent or Firm:
Shunichiro Suzuki
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