Title:
タキキニン受容体アンタゴニストとしてのトリアゾール誘導体
Document Type and Number:
Japanese Patent JP4559087
Kind Code:
B2
Abstract:
This application relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and its use as an inhibitor of the NK-1 subtype of tachykinin receptors, as well as a process for its preparation and intermediates therefor. (I) wherein: D is a C1-C3 alkane-diyl; R1 is phenyl, which is optionally substituted with one to three substitutents independently selected from the group consisting of halo, C1-C4 alkyl, C1-C4 alkoxy, cyano, difluoromethyl, trifluoromethyl, and trifluoromethoxy; R4 is a radical selected from the group consisting of: (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH)
Inventors:
Albert Kuzobi Amegazie
Kevin Matthew Gardener
Eric James Humber
Hong Jiang Eric
Luis Nikolaus Jungaim
Brian Stephen Mule
David Michael Remic
Michael alan robertson
Kenneth Allen Sabin
Kevin Matthew Gardener
Eric James Humber
Hong Jiang Eric
Luis Nikolaus Jungaim
Brian Stephen Mule
David Michael Remic
Michael alan robertson
Kenneth Allen Sabin
Application Number:
JP2003587786A
Publication Date:
October 06, 2010
Filing Date:
April 22, 2003
Export Citation:
Assignee:
Eli Lilly and Company
International Classes:
C07D249/06; A61K31/4192; A61K31/4196; A61K31/422; A61K31/437; A61K31/4439; A61K31/444; A61K31/497; A61K31/4985; A61K31/501; A61K31/5025; A61K31/503; A61K31/506; A61K31/5377; A61K31/541; A61P1/04; A61P1/08; A61P11/06; A61P17/00; A61P25/00; A61P25/04; A61P25/18; A61P25/22; A61P25/24; A61P43/00; C07D249/08; C07D401/04; C07D401/14; C07D403/04; C07D403/14; C07D413/04; C07D413/14; C07D417/14; C07D487/04; C07D498/04
Domestic Patent References:
| JP7330736A |
Foreign References:
| US6060478 | ||||
| WO2001044200A1 |
Other References:
Tetrahedron,1988年,Vol.44, No.12,p.3617-3626
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Masahiro Nitta
Yushiro Tsuboi
Kure Hidenori
Minato Saito
Samejima Mutsumi
Masahiro Nitta
Yushiro Tsuboi
Kure Hidenori
Minato Saito