Title:
3環式アルキルヒドロキサム酸塩、その調製法、およびその細胞増殖抑制剤としての使用法
Document Type and Number:
Japanese Patent JP4142453
Kind Code:
B2
Abstract:
Compounds of formula Iwherein R1, R2, A, X, Y and Z have the meanings provided in the specification, and their enantiomers, diastereoisomers, racemates, pharmaceutically acceptable salts and mixtures thereof. These compounds have HDAC inhibitory activity for inhibiting cell proliferation. Also provided is a process of manufacturing these compounds.
Inventors:
Grossman, Adelbert
Von der Saar, Wolfgang
Zatterkau, Tim
Zibeth, Ulrich
Von der Saar, Wolfgang
Zatterkau, Tim
Zibeth, Ulrich
Application Number:
JP2002583410A
Publication Date:
September 03, 2008
Filing Date:
April 19, 2002
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D209/88; A61K31/165; A61K31/335; A61K31/403; A61K31/55; A61P35/00; A61P43/00; C07C259/06; C07D313/12
Domestic Patent References:
| JP2002080445A | ||||
| JP7502494A | ||||
| JP11502199A |
Foreign References:
| WO1998055449A1 | ||||
| WO1998009934A1 | ||||
| WO2001018171A1 |
Other References:
CHEMISTRY LETTERS, 1992, No.9, pp.1639-1642
European Journal of Pharmacology, 1995, Vol.278, No.2, pp.151-160
European Journal of Pharmacology, 1995, Vol.278, No.2, pp.151-160
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Masaya Nishiyama
Takashi Ishida
Fukumoto product
Tetsuji Koga
Masaya Nishiyama