TRICYCLIC COMPOUND PRODUCING MICROORGANISM

Japanese Patent JP2828091

B2

PROBLEM TO BE SOLVED: To obtain a tricyclic compound comprising a specific tricyclic compound derived from a microorganism belonging to genus Streptomyces, having immunosuppression activities and antimicrobial activities and useful for treatment and prevention of rejection symptom, autoimmune disease and infection disease as a immunosuppression agent and an antimicrobial agent.
SOLUTION: This tricyclic compound is represented by the formula [R1 is a (protected) hydroxy; R2 is H or a (protected) hydroxy; R3 is methyl, ethyl, propyl or allyl; (n) is 1 or 2; a mark represented by a solid line and a dotted line represents a single bond or a double bond], has pharmacological activities such as immunosuppression activities and antimicrobial activities and is useful for treatment, prevention, etc., of rejection symptom caused by transplantation, graft versus host disease caused by bone marrow transplantation, autoimmune disease and infection disease as an immunosuppressiort agent and an antimicrobial agent, etc. The compound is obtained by culturing a microorganism [e.g. Streptomyces tsukubaensis No.9993(FERM 7886] having activities capable of producing the compound of the formula.

OKUHARA MASAKUNI
TANAKA HIROKAZU
GOTO TOSHIO
KINO TOORU
HATANAKA HIROSHI

JP10167397A

November 25, 1998

April 18, 1997

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FUJISAWA YAKUHIN KOGYO KK

A01N43/38; A61K31/00; A61K31/33; A61K31/395; A61K31/40; A61K31/407; A61K31/435; A61K31/4353; A61K31/436; A61K31/445; A61K31/4465; A61K31/4523; A61K31/453; A61K31/4745; A61P31/00; A61P31/04; A61P37/00; A61P37/06; C07D491/14; C07D498/04; C07D498/14; C07D498/18; C07D519/00; C07H19/01; C12N1/20; C12P17/16; C12P17/18; C12P19/44; C12R1/465; C12R1/55; C07D; (IPC1-7): C12N1/20

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