Title:
マトリックスメタロプロテアーゼインヒビターとしての三環式化合物
Document Type and Number:
Japanese Patent JP2010526106
Kind Code:
A
Abstract:
The present teachings relate to compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3, R4, X, and Y are as defined herein. The present teachings also provide methods of making the compounds of formula I and methods of inhibiting matrix metalloproteinases, in particular, MMP-12, that may be involved in pathological disorders found in mammals, including a human.
Inventors:
Lee, Way
Lee, Chiang Chang
Wu, You Chuan
Woo, Chun Chun
Hot Chandani, Rajiv
Steve, Steve
Mansour, Tarek
Cypec, Joseph P.
McFaddien, Ian
Lee, Chiang Chang
Wu, You Chuan
Woo, Chun Chun
Hot Chandani, Rajiv
Steve, Steve
Mansour, Tarek
Cypec, Joseph P.
McFaddien, Ian
Application Number:
JP2010506709A
Publication Date:
July 29, 2010
Filing Date:
May 05, 2008
Export Citation:
Assignee:
Weiss LRC
International Classes:
C07D307/91; A61K31/343; A61K31/36; A61K31/381; A61K31/41; A61K31/4155; A61K31/422; A61K31/4245; A61K31/427; A61K31/433; A61K31/443; A61K31/496; A61K31/506; A61K31/5377; A61P3/04; A61P3/10; A61P9/10; A61P11/00; A61P11/06; A61P17/00; A61P19/00; A61P19/02; A61P25/00; A61P35/00; A61P43/00; C07D333/76; C07D405/04; C07D407/04; C07D409/04; C07D413/04; C07D413/14; C07D417/04; C07D417/14
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita