Title:
TROPICAL EYEDROP COMPOSITION AND PROSTAGLANDIN THEREFOR
Document Type and Number:
Japanese Patent JP2769294
Kind Code:
B2
Abstract:
PURPOSE: To obtain the subject composition which contains a specific prostaglandin homologue as an active ingredient and can lower intraocular pressure accompanied by no side effect.
CONSTITUTION: This composition contains (A) ophthalmologically acceptable vehicle and (B) a therapeutically effective amount of a compound of formula I [R1 is CO2R2 (R2 is H, a cationic salt component), an ophthalmologically acceptable ester component; Y is CH2, O; R3 and R4 are each free hydroxyl, etherified hydroxyl, esterified hydroxyl; n is 0 or 1; = is a single bond, a trans double bond, where in the case that it represents a double bond, X is not Cl or F of the β-configuration]. As a compound of formula I, is preferably that of formula II. This compound is preferably contained in the objective composition in a concentration of 0.00002-0.5wt.%.
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Inventors:
Sally, Bernie El.
De Santis, Lewis Jr.
Tincke, Paul W.
Bishop, John Yi.
Crimco, Peter G.
Celia, Robert Dee.
Dean, Thomas Earl.
Herberg, Mark Earl.
De Santis, Lewis Jr.
Tincke, Paul W.
Bishop, John Yi.
Crimco, Peter G.
Celia, Robert Dee.
Dean, Thomas Earl.
Herberg, Mark Earl.
Application Number:
JP33290994A
Publication Date:
June 25, 1998
Filing Date:
December 15, 1994
Export Citation:
Assignee:
Archon Laboratories, Inc.
International Classes:
A61K31/557; A61K31/5575; A61P27/02; C07C405/00; C07D207/337; C07D213/55; C07D307/54; C07D333/24; (IPC1-7): A61K31/557; C07C405/00
Domestic Patent References:
| JP8500597A | ||||
| JP63500795A | ||||
| JP6147459A | ||||
| JP296528A | ||||
| JP296529A | ||||
| JP2108A | ||||
| JP6366122A | ||||
| JP63107927A |
Attorney, Agent or Firm:
Tsuyoshi Watanabe (1 person outside)