Title:
腫瘍診断剤
Document Type and Number:
Japanese Patent JP5836402
Kind Code:
B2
Abstract:
It is to provide a tumor diagnostic agent and a tumor determination method enabling not only determination of the presence or absence of a tumor in a subject, but also determination of whether the tumor is a malignant tumor or a benign tumor, which can be used simply at low cost with reduced side effects and burden. 5-aminolevulinic acid (ALA) or its derivative, or a salt thereof is orally administered at a dose of 5 to 7 mg in terms of ALA per kg of body weight, and a urine sample 4 to 12 hours after the administration is collected. Porphyrins and creatinine in the urine sample are quantitated, and based on the value (nmol/gCre) obtained by dividing the amount of porphyrins by the amount of creatinine, a distinction among an individual without a tumor, an individual with a benign tumor, and an individual with a malignant tumor is determined. The presence or absence of a malignant tumor in a subject can be clearly determined by administering 1 to 3 mg of ALAs in terms of ALA per kg of body weight.
Inventors:
Toru Tanaka
Research Takahashi
Nakajima Motoo
Abe Fumi
Masahiro Ishizuka
Ota Rei
Research Takahashi
Nakajima Motoo
Abe Fumi
Masahiro Ishizuka
Ota Rei
Application Number:
JP2013555180A
Publication Date:
December 24, 2015
Filing Date:
January 15, 2013
Export Citation:
Assignee:
SBI Pharma Co., Ltd.
International Classes:
A61K49/00; G01N33/574; G01N33/70; G01N33/72
Domestic Patent References:
| JP5310576A | ||||
| JP2006124372A | ||||
| JP4500676A | ||||
| JP2009524415A |
Attorney, Agent or Firm:
Masaki Hirota
Seiji Ozawa
Yusaku Tokai
Makoto Horiuchi
Seiji Ozawa
Yusaku Tokai
Makoto Horiuchi