Title:
α−トルキシル酸誘導体およびその医薬組成物
Document Type and Number:
Japanese Patent JP6976581
Kind Code:
B2
Abstract:
The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, said compound having the structure: Formula
Inventors:
Ojima, Iwao
Deutsch, Dale
Martin, Cassocha
Huh, Congen
Tong, Simon
Hermes, Matthew
Yang, Su
Deutsch, Dale
Martin, Cassocha
Huh, Congen
Tong, Simon
Hermes, Matthew
Yang, Su
Application Number:
JP2018567019A
Publication Date:
December 08, 2021
Filing Date:
March 10, 2017
Export Citation:
Assignee:
The Research Foundation for the State University of New York
International Classes:
C07C69/753; A61K31/235; A61K31/351; A61K31/4192; A61K31/47; A61P25/00; A61P25/04; A61P25/24; A61P25/30; A61P29/00; A61P43/00; C07C69/757; C07D215/32; C07D249/06; C07D309/06
Domestic Patent References:
| JP2011507910A | ||||
| JP2002154959A |
Foreign References:
| ES2189602A1 | ||||
| WO2014015276A1 |
Other References:
REGISTRY(STN)[online],2003年03月12日,[検索日 2020.12.11] CAS登録番号:497916-43-5
REGISTRY(STN)[online],2002年11月14日,[検索日 2020.12.11] CAS登録番号:473573-87-4
REGISTRY(STN)[online],2001年07月23日,[検索日 2020.12.11] CAS登録番号:347362-81-6
Kaczocha, Martin et al. ,Inhibition of fatty acid binding proteins elevates brain anandamide levels and produces analgesia,PLoS One,2014年,9(4),,e94200/1-e94200/10, 10
Steri, Ramona et al.,Truxillic acid derivatives act as peroxisome proliferator-activated receptor γ activators,Bioorganic & Medicinal Chemistry Letters,2010年,20(9),,2920-2923
Takeda, Reiji et al.,The first isolation of lignans, megacerotonic acid and anthocertotonic acid, from nonvascular plants, Anthocerotae (Hornworts).,Tetrahedron Letters,1990年,31(29),,4159-62
Arendaruk, A. P.; Skoldinov, A. P.,Cyclobutanedicarboxylic acids. III. Basic esters of α-truxillic acid,Zhurnal Obshchei Khimii,1960年,30,,2743-5
REGISTRY(STN)[online],2002年11月14日,[検索日 2020.12.11] CAS登録番号:473573-86-3
REGISTRY(STN)[online],2002年11月14日,[検索日 2020.12.11] CAS登録番号:473573-87-4
REGISTRY(STN)[online],2001年07月23日,[検索日 2020.12.11] CAS登録番号:347362-81-6
Kaczocha, Martin et al. ,Inhibition of fatty acid binding proteins elevates brain anandamide levels and produces analgesia,PLoS One,2014年,9(4),,e94200/1-e94200/10, 10
Steri, Ramona et al.,Truxillic acid derivatives act as peroxisome proliferator-activated receptor γ activators,Bioorganic & Medicinal Chemistry Letters,2010年,20(9),,2920-2923
Takeda, Reiji et al.,The first isolation of lignans, megacerotonic acid and anthocertotonic acid, from nonvascular plants, Anthocerotae (Hornworts).,Tetrahedron Letters,1990年,31(29),,4159-62
Arendaruk, A. P.; Skoldinov, A. P.,Cyclobutanedicarboxylic acids. III. Basic esters of α-truxillic acid,Zhurnal Obshchei Khimii,1960年,30,,2743-5
REGISTRY(STN)[online],2002年11月14日,[検索日 2020.12.11] CAS登録番号:473573-86-3
Attorney, Agent or Firm:
Kurata Masatoshi
Nobuhisa Nogawa
Naoki Kono
Tadashi Inoue
Ukai Ken
Shigeru Iino
Nobuhisa Nogawa
Naoki Kono
Tadashi Inoue
Ukai Ken
Shigeru Iino