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Title:
ＲＨＯキナーゼ阻害剤としてのチロシンアミド誘導体
Document Type and Number:
Japanese Patent JP2021529819
Kind Code:
A
Abstract:
本発明は、二環式ジヒドロピリミジン−カルボキサミド誘導体である、Rhoキナーゼを阻害する式Ｉの化合物、このような化合物の調製方法、それを含有する医薬組成物、及びその処置的使用に関する。具体的には、本発明の化合物は、喘息、慢性閉塞性肺疾患（COPD）、特発性肺線維症（IPF）、及び肺動脈性高血圧症（PAH）を含む肺疾患等のROCK酵素の機序に関連する多くの障害の処置において有用であり得る。

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Inventors:
Accetta Alessandro
Rankati, Fabio
Anna Maria, Capelli
Clark, David Edward
Tisseli, Patrizia
Edwards, christine
Shuguiyomu, Arnaud Jean Francois Auguste
Burleigh, Gourdip
Application Number:
JP2021501323A
Publication Date:
November 04, 2021
Filing Date:
July 12, 2019
Export Citation:
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Assignee:
Chiesie Falmatie Uteichi Esset Pi A
International Classes:
C07D471/04; A61K31/437; A61K31/4375; A61K31/4545; A61K31/519; A61K45/00; A61P9/12; A61P11/00; A61P11/06; A61P43/00; C07D487/04; C07D519/00
Domestic Patent References:
JP2020505328A2020-02-20
JP7208142B22023-01-18
JP2007532502A2007-11-15
JP2009506979A2009-02-19
JP2011513450A2011-04-28
JP2008530242A2008-08-07
Other References:
YANGBO FENG ET AL: "Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential", J. MEDICINAL CHEMISTRY, vol. Vol.59(6), JPN6023029291, 2016, pages 2269 - 2300, ISSN: 0005108820
Attorney, Agent or Firm:
Patent business corporation Tsukuni



 
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