Title:
USE OF ERBB3 INHIBITORS IN TREATMENT OF TRIPLE NEGATIVE AND BASAL-LIKE BREAST CANCERS
Document Type and Number:
Japanese Patent JP2016166203
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide methods for treating triple negative breast cancers (e.g., tumors) and basal-like breast cancers (e.g., tumors), and pharmaceutical compositions for use in the methods.SOLUTION: An ErbB3 inhibitor for use in a method of treatment of triple negative breast cancers is an anti-ErbB3 antibody having specific Vand Vsequences. A method of using the ErbB3 inhibitor preferably comprises administering an additional anti-cancer agent that is not an ErbB3 inhibitor.SELECTED DRAWING: None
Inventors:
VICTOR MOYO
GABRIELA GARCIA
GABRIELA GARCIA
Application Number:
JP2016045111A
Publication Date:
September 15, 2016
Filing Date:
March 09, 2016
Export Citation:
Assignee:
MERRIMACK PHARMACEUTICALS INC
International Classes:
A61K39/395; A61K31/337; A61K45/00; A61P15/00; A61P35/00; A61P43/00
Foreign References:
| WO2010019952A2 | 2010-02-18 |
Other References:
CANCER INVESTIGATION, vol. 27, no. 6, JPN6015008611, 2009, pages 613 - 623, ISSN: 0003467114
SCHOEBERL BIRGIT: "AN ERBB3 ANTIBODY MM-121,IS ACTIVE IN CANCERS WITH LIGAND-DEPENDENT ACTIVATION", CANCER RESEARCH, vol. V70 N6, JPN5013004566, 9 March 2010 (2010-03-09), pages 2485 - 2494, ISSN: 0003467115
SCHNEIDER B P: "TRIPLE-NEGATIVE BREAST CANCER: RISK FACTORS TO POTENTIAL TARGETS", CLINICAL CANCER RESEARCH, vol. V14 N24, JPN5013004568, 15 December 2008 (2008-12-15), US, pages 8010 - 8018, ISSN: 0003467116
HARRIS LYNDSAY N: "MOLECULAR SUBTYPES OF BREAST CANCER IN RELATION TO PACLITAXEL RESPONSE AND OUTCOMES 以下備考", BREAST CANCER RESEARCH, vol. V8 N6, JPN5013004567, 27 November 2006 (2006-11-27), GB, pages 66, ISSN: 0003467117
SCHOEBERL BIRGIT: "AN ERBB3 ANTIBODY MM-121,IS ACTIVE IN CANCERS WITH LIGAND-DEPENDENT ACTIVATION", CANCER RESEARCH, vol. V70 N6, JPN5013004566, 9 March 2010 (2010-03-09), pages 2485 - 2494, ISSN: 0003467115
SCHNEIDER B P: "TRIPLE-NEGATIVE BREAST CANCER: RISK FACTORS TO POTENTIAL TARGETS", CLINICAL CANCER RESEARCH, vol. V14 N24, JPN5013004568, 15 December 2008 (2008-12-15), US, pages 8010 - 8018, ISSN: 0003467116
HARRIS LYNDSAY N: "MOLECULAR SUBTYPES OF BREAST CANCER IN RELATION TO PACLITAXEL RESPONSE AND OUTCOMES 以下備考", BREAST CANCER RESEARCH, vol. V8 N6, JPN5013004567, 27 November 2006 (2006-11-27), GB, pages 66, ISSN: 0003467117
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto
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