Title:
頭蓋内圧亢進の急性減少のための抗ヒスタミン剤の使用
Document Type and Number:
Japanese Patent JP4991770
Kind Code:
B2
Abstract:
The invention concerns the use of an H1- and/or H2-histamine receptor antagonist for the reduction of intracranial pressure (ICP), in particular for the prevention and treatment of elevated intracranial pressure and/or secondary ischaemia, in particular caused by brain injury, more in particular caused by traumatic (TBI) and non-traumatic brain injury. In particular, the histamine antagonist is selected from the group of acrivastine, alimemazine, antazoline, astemizole, azatadine, azelastine, brompheniramine, buclizine, carbinoxamine, carebastine, cetirizine, chlorcyclizine, chlorpheniramine, cinnarizine, clemastine, clemizole, clocinizine, clonidine, cyclizine, cyproheptadine, descarboethoxyloratidine, dexchlorpheniramine, dimenhydrinate, dimethindene, dimethothiazine, diphenhydramine, diphenylpyraline, doxylamine, ebastine, efletirizine, epinastine, fexofenadine, hydroxyzine, ketotifen, levocabastine, loratidine, meclizine, mequitazine, methdilazine, mianserin, mizolastine, niaprazine, noberastine, norastemizole, oxatomide, oxomemazine, phenbenzamine, pheniramine, picumast, promethazine, pyrilamine, temelastine, terfenadine, trimeprazine, tripelennamine, triprolidine, ranitidine, cimetidine, famotidine, nizatidine, tiotidine, zolantidine, ritanserine, and derivatives thereof and mixtures of any two or more of the foregoing.
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Inventors:
Frank Tegtomier
Fran Edouard Jiansen
Joseph Elisabeth Rehnertz
Kenrath Altwool Van Rothem
Manuel Jesus Alcazar-Baka
Pedro Martinez-Jimenes
Jose Manuel Bartolome-Nebreda
Antonio Gomez-Santies
Francisco Xavier Fernandez-Gadea
Joseph Leo Henry Van Lempts
Fran Edouard Jiansen
Joseph Elisabeth Rehnertz
Kenrath Altwool Van Rothem
Manuel Jesus Alcazar-Baka
Pedro Martinez-Jimenes
Jose Manuel Bartolome-Nebreda
Antonio Gomez-Santies
Francisco Xavier Fernandez-Gadea
Joseph Leo Henry Van Lempts
Application Number:
JP2009023575A
Publication Date:
August 01, 2012
Filing Date:
February 04, 2009
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
A61K31/135; A61K31/415; C07D487/04; A61K31/425; A61K31/44; A61K31/513; A61K31/517; A61K31/519; A61K31/54; A61K31/55; A61P1/04; A61P3/00; A61P9/10; A61P29/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D471/00; C07D471/04; C07D487/00; C07D519/00
Domestic Patent References:
| JP2004536821A |
Foreign References:
| US6251894 | ||||
| WO1999013871A1 |
Other References:
S. MOHANTY,JOURNAL OF THE NEUROLOGICAL SCIENCES,1989年,V90,P87-97
Attorney, Agent or Firm:
Patent business corporation Odashima patent office