Title:
細胞におけるアポトシスの誘発のための抗黄体ホルモンの使用
Document Type and Number:
Japanese Patent JP2004511523
Kind Code:
A
Abstract:
The present invention relates to methods and uses for inducing apoptosis in a cell, in particular a breast cancer cell, by the administration of antiprogestins, in particular the antiprogestin 11 beta -(4-acetylphenyl)-17 beta -hydroxy-17 alpha -(1,1,2,2,2-pentaf luoroeth yl)-estra-4,9-dien-3-one or a pharmaceutically acceptab le derivative or analogue thereof. The invention further relates to a treatment of cancer wherein an indicator of high risk is an increased amount of tumor cells in the S-phase of the cell cycle, said treatment comprising an antiprogestin, in particular the antiprogestin 11 beta -(4-acetylphenyl)-17 beta -hydroxy-17 alpha -(1, 1,2, 2,2- pentafluoroethyl)-estra-4,9-dien-3-one or a pharmaceutically acceptable derivative or analogue thereof.
Inventors:
Hoffman, Jens
Richterner, Rosemary
Gee Meister, Gerd
Schneider, martin
Furman, Ulrike
Richterner, Rosemary
Gee Meister, Gerd
Schneider, martin
Furman, Ulrike
Application Number:
JP2002535670A
Publication Date:
April 15, 2004
Filing Date:
October 17, 2001
Export Citation:
Assignee:
Schering Actien Gezel Shaft
International Classes:
A61K31/57; A61P35/00; A61P43/00; C07J7/00; (IPC1-7): A61K31/57; A61P35/00; A61P43/00; C07J7/00
Attorney, Agent or Firm:
Takashi Ishida
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji