Title:
癌治療のためのアリールアルデヒド5-オキソ-1,2,4-トリアジンヒドラジドの使用
Document Type and Number:
Japanese Patent JP2004505055
Kind Code:
A
Abstract:
This invention is a method of treating cancer, including carcinomas and sarcomas, through the administration of a pharmaceutical composition containing an arylaldehyde 5-oxo-1,2,4-triazine hydrazide derivative. The arylaldehyde 5-oxo-1,2,4-triazine hydrazide derivative is selected from the group consisting of those with the formula:wherein R and R1 are independently selected from the group consisting of hydrogen and alkyl wherein the alkyl group has up to 7 carbon atoms; or a pharmaceutical salt thereof; a prodrug thereof; a metabolite thereof; and mixtures thereof. Pharmaceutical compositions comprising these compounds and their use in various treatment methods are claimed. The compounds can be used in conjunction with other chemotherapeutic agents and potentiators.
Inventors:
James Burger Camden
Application Number:
JP2002515268A
Publication Date:
February 19, 2004
Filing Date:
July 25, 2001
Export Citation:
Assignee:
The University of Arizona Foundation
International Classes:
C07D253/06; A61K31/53; A61K45/00; A61P35/00; A61P35/02; A61P43/00; C07D253/075; (IPC1-7): A61K31/53; A61K45/00; A61P35/00; A61P35/02; A61P43/00; C07D253/06
Attorney, Agent or Firm:
Yoshikazu Tani
Kazuo Abe
Kazuo Abe