Title:
２−アミノ−ベンゾイミダゾール誘導体ならびにこれらの５−リポキシゲナーゼおよび／またはプロスタグランジンＥシンターゼ阻害剤としての使用
Document Type and Number:
Japanese Patent JP6785217
Kind Code:
B2
Abstract:
The present invention relates to benzimidazole derivatives having the general formula I, wherein n is 0 or 1; X1 and X2 are independently, at each occurrence, CR5 or N; Y is C1-C6 alkylene, wherein alkylene is optionally substituted with one to two C1-C3 alkyl groups; R1 is selected from the group consisting of hydrogen, halogen, C1-C6 alkoxy, —NH2, —NHR6, —NR7R8 and —NH—(R9)n—R10, n being 0 or 1; R2 is selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, —NH2, —NHR6, —NR7R8 and —NH—(R9)n—R10; R3 is selected from the group consisting of hydrogen, hydroxyl, OR11, —NR7R8, C1-C6 alkoxy, C1-C6 alkyl, C3-C10 cycloalkyl, C1-C3 haloalkyl, —C(O)NHR11, aryl, heteroaryl and heterocyclyl, wherein each of said cycloalkyl, aryl, heteroaryl and heterocyclyl is optionally and independently substituted with one to four Ra groups; and R4 is selected from the group consisting of —NH2, —N(R12)(V)pR13, —NH(V)p—OR14, —NHC(O)R15, and groups of formula 1a shown below, and their use in the treatment of diseases, in particular inflammatory diseases, cancer, stroke and/or Alzheimer's disease.
Inventors:
Kim, jesus
Anne, Seohyun
John, Ijin
Park, Dongsik
Yang, Yong-In
Lee, Do Hyun
Lee, Saeyeon
Anne, Jie
Kim, jung jun
Nam, Kyon
Kang, Seung Hee
Seo, Min Jung
Seo, Muyoung
Seo, Jung Jae
Han, Sun-John
Kim, john fan
Lee, Suntur
Choi, Gahi
Lee, Yunmi
Anne, Seohyun
John, Ijin
Park, Dongsik
Yang, Yong-In
Lee, Do Hyun
Lee, Saeyeon
Anne, Jie
Kim, jung jun
Nam, Kyon
Kang, Seung Hee
Seo, Min Jung
Seo, Muyoung
Seo, Jung Jae
Han, Sun-John
Kim, john fan
Lee, Suntur
Choi, Gahi
Lee, Yunmi
Application Number:
JP2017504727A
Publication Date:
November 18, 2020
Filing Date:
July 31, 2015
Export Citation:
Assignee:
Institute Pasteur Korea
CURYENT COMPANY, LIMITED
CURYENT COMPANY, LIMITED
International Classes:
C07D235/30; A61K31/4184; A61K31/422; A61K31/423; A61K31/437; A61K31/4439; A61K31/444; A61K31/4709; A61K31/4725; A61K31/496; A61K31/497; A61K31/498; A61K31/501; A61K31/506; A61K31/517; A61K31/5377; A61P1/04; A61P9/10; A61P9/12; A61P11/00; A61P11/02; A61P11/06; A61P17/02; A61P19/02; A61P25/00; A61P25/04; A61P25/28; A61P29/00; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D401/12; C07D401/14; C07D403/12; C07D403/14; C07D405/12; C07D405/14; C07D409/14; C07D413/12; C07D413/14; C07D417/14; C07D471/04
Domestic Patent References:
| JP2005524668A |
Foreign References:
| WO2005079791A1 | ||||
| CN103450093A |
Other References:
Database CAPlus [Online]: Chemical Abstracts Service, Columbus, Ohio ISA.,1970年,Retrieved from STN,Accession Number (AN) 1971:76370,Document Number(DN) 74:76370 ;retrieved on 26 March 2019
Database REGISTRY,2014年 2月,RN 1541140-87-7,1538868-99-3, 1536367-51-7, Retrieved from STN international [online] ;retrieved on 26 March 2019
Database REGISTRY,2014年 1月,RN 1533522-00-7,1529280-72-5, 1528005-29-9, 1525796-75-1, 1522954-74-0, 1519422-08-2, 1519204-85-3, 1518877-77-4, 1515668-46-8, 1515498-66-4, 1511796-36-3, 1508803-33-5, Retrieved from STN international [online] ;retrieved on 26 March 2019
Database REGISTRY,2013年,RN 1499579-70-2, Retrieved from STN international [online] ;retrieved on 26 March 2019
Database REGISTRY,2014年 2月,RN 1542936-92-4,1541791-05-2, 1540199-07-2, 1538037-44-3, 1536347-19-9, Retrieved from STN international [online] ;retrieved on 26 March 2019
Database REGISTRY,2014年 1月,RN 1528291-55-5,1520640-87-2, 1510964-30-3, Retrieved from STN international [online] ;retrieved on 26 March 2019
Database REGISTRY,2013年,RN 1505029-19-5,1504134-40-0, 1502798-39-1, 1502412-99-8, Retrieved from STN international [online] ;retrieved on 26 March 2016
Database REGISTRY,2014年 1月,RN 1514001-71-8,RN 1513940-72-1, RN 1513055-12-3, Retrieved from STN international [online] ;retrieved on 26 March 2019
Database REGISTRY,2014年 2月,RN 1541140-87-7,1538868-99-3, 1536367-51-7, Retrieved from STN international [online] ;retrieved on 26 March 2019
Database REGISTRY,2014年 1月,RN 1533522-00-7,1529280-72-5, 1528005-29-9, 1525796-75-1, 1522954-74-0, 1519422-08-2, 1519204-85-3, 1518877-77-4, 1515668-46-8, 1515498-66-4, 1511796-36-3, 1508803-33-5, Retrieved from STN international [online] ;retrieved on 26 March 2019
Database REGISTRY,2013年,RN 1499579-70-2, Retrieved from STN international [online] ;retrieved on 26 March 2019
Database REGISTRY,2014年 2月,RN 1542936-92-4,1541791-05-2, 1540199-07-2, 1538037-44-3, 1536347-19-9, Retrieved from STN international [online] ;retrieved on 26 March 2019
Database REGISTRY,2014年 1月,RN 1528291-55-5,1520640-87-2, 1510964-30-3, Retrieved from STN international [online] ;retrieved on 26 March 2019
Database REGISTRY,2013年,RN 1505029-19-5,1504134-40-0, 1502798-39-1, 1502412-99-8, Retrieved from STN international [online] ;retrieved on 26 March 2016
Database REGISTRY,2014年 1月,RN 1514001-71-8,RN 1513940-72-1, RN 1513055-12-3, Retrieved from STN international [online] ;retrieved on 26 March 2019
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takeshi Komatani
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takeshi Komatani
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto