真菌株から由来の新規な２４員のシクロオクタデプシペプチドおよびその駆虫剤または内部寄生虫駆除剤としての使用

Japanese Patent JP5779787

B2

The present invention relates firstly to the discovery of the previously unknown 24-membered cyclooctadepsipeptides PF1022-V, PF1022-W, XRB-C894, XRB-C942, XRB-C976, XRB-C1010, XRB-C1044, XRB-E922, XRB-E956, XRB-E990, XRB-E1024, XRB-S958, XRB-S992, XRB-S1026, XRB-S1060 (in various isomeric forms) and to the processes for the preparation of the abovementioned cyclooctadepsipeptides by means of the fungal strains from the family Xylariaceae, in particular the genera Rosellinia and Coniolariella, and by means of the mitosporic fungal strains from the groups Fusarium, Beauveria and Verticillium (orders Hypocreales and Phyllachorales), and by means of the enzymatic preparations isolated from these fungal strains, and secondly to the use of these strains for the preparation of the abovementioned novel cyclooctadepsipeptides and to the use of bassianolide and of the abovementioned novel cyclooctadepsipeptides individually or as a mixture, as anthelmintics or endoparasiticides.

Achim Halder
Clemens Krieger
Thi Lam Huong Fum
Tan Dam Finn
Ilm Trout Tspel
Dietrich Ewald
Clemens Mugge
Haldi Vaishov

JP2012542507A

September 16, 2015

December 07, 2010

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Bayer Intellectual Property GmbH

C07K11/02; A01N43/72; A61K31/5395; A61P33/10; C07D273/00

JP3035796A
JP5170749A
JP6184126A

Makoto Ono
Kenkyo Kanayama
Mitsuaki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Takahiro Aoki
Yoshie Sakurada
Yousuke Kawasaki
Toshikazu Imato
Yoshikazu Iwase
Yasufumi Shiroyama

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