Title:
ポリペプチドの産生のための細胞培養における銅およびグルタミン酸塩の使用
Document Type and Number:
Japanese Patent JP5586235
Kind Code:
B2
Abstract:
An improved system for large scale production of polypeptides in cell culture is provided. In accordance with the present invention, cells expressing a polypeptide of interest are grown in media that contain copper, glutamate or both. The use of such a system allows production of polypeptides in which misfolding and/or aggregation are reduced, and in which total glycosylation is increased. Polypeptides expressed in accordance with the present invention may be advantageously used in the preparation of pharmaceutical, agricultural or other commercial compositions.
Inventors:
Drapeau and Dennis
Snow and Jessica
Hiller and Gregory
Rouen and Ieng Tongue
Snow and Jessica
Hiller and Gregory
Rouen and Ieng Tongue
Application Number:
JP2009551867A
Publication Date:
September 10, 2014
Filing Date:
February 29, 2008
Export Citation:
Assignee:
Weiss LLC
International Classes:
C12P21/02; C12N5/10
Attorney, Agent or Firm:
Four 能尚
Koji Takahashi
Junko Miyazawa
Masanori Sato
Koji Takahashi
Junko Miyazawa
Masanori Sato
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