Title:
抗腫瘍剤としてのエストロン誘導体の使用
Document Type and Number:
Japanese Patent JP5042411
Kind Code:
B2
Abstract:
There is provided use of a cyclic compound or a pharmaceutically active salt thereof in the manufacture of a medicament to prevent and/or inhibit and/or arrest cell cycling, wherein the cyclic compound comprises at least one ring, wherein Group I and Group II, independently of each other, are attached to a ring of the cyclic compound; wherein Group I is a hydrocarbyl or an oxyhydrocarbyl group; and wherein Group II is a group of the formula X is P or S; when X is P, Y is ═O or S, Z is —OH and R is hydrocarbyl or H; when X is S, Y is ═O, Z is ═O, and R is hydrocarbyl or N(R1)(R2), wherein each of R1 and R2 is independently selected from H or a hydrocarbyl group.
Inventors:
Reed, michael john
Potter, Barry Victor Lloyd
Potter, Barry Victor Lloyd
Application Number:
JP2000614980A
Publication Date:
October 03, 2012
Filing Date:
April 28, 2000
Export Citation:
Assignee:
Sterix limited
International Classes:
A61K31/565; A61K31/352; A61P35/00; C07J1/00
Foreign References:
| WO1998024802A1 |
Other References:
PUROHIT, A. et al.,JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY,英国,1998年,Vol.64, No.5,p.269-275
CUSHMAN, M. et al.,JOURNAL OF MEDICINAL CHEMISTRY,米国,1995年,Vol.38, No.12,p.2041-2049
KLAUBER, N. et al.,CANCER RESEARCH,1997年,Vol.57, No.1,p.81-86
KOSSODO, S. et al.,British Journal of Cancer,1995年,Vol.72,p.1165-1172
BUDD, G.T. et al.,Cancer,1991年,Vol.68, No.8,p.1694-1695
CUSHMAN, M. et al.,JOURNAL OF MEDICINAL CHEMISTRY,米国,1995年,Vol.38, No.12,p.2041-2049
KLAUBER, N. et al.,CANCER RESEARCH,1997年,Vol.57, No.1,p.81-86
KOSSODO, S. et al.,British Journal of Cancer,1995年,Vol.72,p.1165-1172
BUDD, G.T. et al.,Cancer,1991年,Vol.68, No.8,p.1694-1695
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita