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Title:
USE OF GLYCOSIDE OF MONO- AND DIACYLGLYCEROL AS ANTI-INFLAMMATORY AGENT
Document Type and Number:
Japanese Patent JP2010215660
Kind Code:
A
Abstract:

To provide new use of glycoside of mono- and diacylglycerol, for example, 3-β-D-galactopyranosyloxy-2-(octadeca-9Z, 12Z, 15Z-trienoyloxy)propanyl octadeca-9Z, 12Z, 15Z-trienoate which is a component of rose-hips (fruits of Rosa canina L.).

It is found that glycosides of diacylglycerol isolated from extracts of rose-hips, for example 3-β-D-galactopyranosyloxy-2-(octadeca-9Z, 12Z, 15Z-trienoyloxy)propanyl octadeca-9Z, 12Z, 15Z-trienoate (GOPO) (A) can be used as an anti-inflammatory agent for the treatment of inflammatory diseases such as arthritis and osteoarthrosis.


Inventors:
LARSEN ERIK
KHARAZMI ARSALAN
CHRISTENSEN SOEREN BROEGGER
CHRISTENSEN LARS PORSKJAER
BRANDT KIRSTEN
Application Number:
JP2010142945A
Publication Date:
September 30, 2010
Filing Date:
June 23, 2010
Export Citation:
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Assignee:
DANMARKS JORDBRUGSFORSKNING
RIGSHOSPITALET
DANMARKS FARMACEUTISKE UNIV
International Classes:
A61K31/7032; C07H15/10; A61K31/00; A61K31/70; A61K31/7012; A61K31/7024; A61K45/00; A61P1/04; A61P1/16; A61P3/10; A61P9/00; A61P9/10; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P25/28; A61P29/00; A61P31/04; A61P35/00; A61P37/06; A61P37/08; A61P39/06; C07H15/04; C07H15/06
Domestic Patent References:
JPH07149786A1995-06-13
JPH06336437A1994-12-06
Foreign References:
WO1999053934A11999-10-28
Other References:
JPN6009029847; Chem.Pharm.Bull. 39(5), 1991, pp.1337-1339
JPN6009029848; Pharm Pharmacol Lett vol.2, 2001, pp.53-57
JPN6009029850; Kor.J.Pharmacogn. 31(1), 2000, pp.95-100
Attorney, Agent or Firm:
Aoyama Aoi
Mitsuo Tanaka
Mitsutaka Iwasaki