Title:
生体分子標識用複素環FRET色素カセット並びにDNA配列決定での使用
Document Type and Number:
Japanese Patent JP2006511581
Kind Code:
A
Abstract:
Exploitation of suitably functionalized heterocyclic molecules, in the design and synthesis of Fluorescence Resonance Energy Transfer (FRET) cassettes and their corresponding dideoxynucleotide terminators culminated into efficient reagents for DNA sequencing. Additionally, these FRET cassettes/terminators, of the present invention, derived from different classes of heterocyclic systems have high potential to be used for general labelling of biological molecules to generate highly sensitized signals. Their preparation, energy transfer efficiency, and use as labels, specifically, in DNA sequencing reactions is disclosed.
Inventors:
Nampali, Thatcham
Tsang, Weihong
Lao, Sudaka
Shiv, Kumar
Tsang, Weihong
Lao, Sudaka
Shiv, Kumar
Application Number:
JP2004563814A
Publication Date:
April 06, 2006
Filing Date:
December 17, 2003
Export Citation:
Assignee:
Amersham Biosciences Corp
International Classes:
C07D405/14; C07D491/22; C07H21/04; C09B11/08; C09B11/24; C09B11/28; C09B23/08; C09B69/00; C12Q1/68; G01N33/53; G01N33/533; G01N33/566
Attorney, Agent or Firm:
Kenichi Matsumoto
Hirokazu Ogura
Nobukazu Ito
Toshihisa Kurokawa
Hirokazu Ogura
Nobukazu Ito
Toshihisa Kurokawa