Title:
神経幹細胞の増殖および神経発生のための黄体化ホルモン(LH)、および絨毛性ゴナドトロピン(hCG)の使用
Document Type and Number:
Japanese Patent JP4990634
Kind Code:
B2
Abstract:
The present invention provides a method of increasing neural stem cell numbers or neurogenesis by using a pheromone, a luteinizing hormone (LH) and/or a human chorionic gonadotrophin (hCG). The method can be practiced in vivo to obtain more neural stem cells in situ, which can in turn produce more neurons or glial cells to compensate for lost or dysfunctional neural cells. The method can also be practiced in vitro to produce a large number of neural stem cells in culture. The cultured stem cells can be used, for example, for transplantation treatment of patients or animals suffering from or suspected of having neurodegenerative diseases or conditions.
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Inventors:
Weiss, Samuel
Enwar, Emeka
Andersen, Linda
Greg, Christopher
Enwar, Emeka
Andersen, Linda
Greg, Christopher
Application Number:
JP2006552438A
Publication Date:
August 01, 2012
Filing Date:
February 14, 2005
Export Citation:
Assignee:
Stem Cell Therapeutics Corporation
International Classes:
A61K38/24; A61K35/30; A61K38/09; A61K38/17; A61K38/18; A61K38/22; A61K38/25; A61K38/27; A61K38/30; A61P25/00; A61P25/28; A61P43/00; C12N5/0797; A61K35/12
Foreign References:
| WO2004045592A1 | ||||
| WO2003018782A1 |
Other References:
SHINGO, T., et al.,Erythropoietin Regulates the In Vitro and In Vivo Production of Neuronal Progenitors by Mammalian Forebrain Neural Stem Cells,The Journal of Neuroscience,2001年12月15日,Vol.21, No.24,p.9733-9743
RAO, S.C., et al.,Human chorionic gonadotropin/leteinizing hormone receptor expression in the adult rat spinal cord,Neuroscience letters,2003年,Vol.336,p.135-138
AL-HADER, A.A., et al.,Neurons from Fetal Rat Brains Contain Functional Luteinizing Hormone/Chorionic Gonadotropin Receptors,BIOLOGY OF REPRODUCTION,1997年,Vol.56,p.1071-1076
AL-HADER, A.A., et al.,Novel Expression of Functional Luteinizing Hormone/Chorionic Gonadotropin Receptors in Cultured Glinal Cells from Neonatal Rat Brains,BIOLOGY OF REPRODUCTION,1997年,Vol.56,p.501-507
新郷哲郎, 他.,1080 一般演題ポスター「神経再生移植(2)」妊娠期に生じるプロラクチンを介したニューロン新生,日本脳神経外科学会総会抄録集,日本,2003年10月 1日,Vol.62nd No.CD-ROM Abstracts,p.262
新郷哲郎,妊娠中に生じるニューロン新生に対するプロラクチンの関与,医学のあゆみ,日本,2003年 4月26日,Vol.205, No.4,p.278-279
REYNOLDS, B.A., et al.,Clonal and Population Analyses Demonstrate That an EGF-Responsisve Mammalian Embryonic CNS Precursor Is a Stem Cell,DEVELOPMENTAL BIOLOGY,1996年,Vol.175,p.1-13
SHINGO, T., et al.,Pregnancy-Stimulated neurogenesis in the Adult Female Forebrain mediated by Prolactin,SCIENCE,2003年 1月 3日,Vol.299,p.117-120
大多茂樹, 他.,神経幹細胞と神経ペプチド,日本内分泌学会雑誌,日本,2003年 9月20日,Vol.79, No.2,p.356
RAO, S.C., et al.,Human chorionic gonadotropin/leteinizing hormone receptor expression in the adult rat spinal cord,Neuroscience letters,2003年,Vol.336,p.135-138
AL-HADER, A.A., et al.,Neurons from Fetal Rat Brains Contain Functional Luteinizing Hormone/Chorionic Gonadotropin Receptors,BIOLOGY OF REPRODUCTION,1997年,Vol.56,p.1071-1076
AL-HADER, A.A., et al.,Novel Expression of Functional Luteinizing Hormone/Chorionic Gonadotropin Receptors in Cultured Glinal Cells from Neonatal Rat Brains,BIOLOGY OF REPRODUCTION,1997年,Vol.56,p.501-507
新郷哲郎, 他.,1080 一般演題ポスター「神経再生移植(2)」妊娠期に生じるプロラクチンを介したニューロン新生,日本脳神経外科学会総会抄録集,日本,2003年10月 1日,Vol.62nd No.CD-ROM Abstracts,p.262
新郷哲郎,妊娠中に生じるニューロン新生に対するプロラクチンの関与,医学のあゆみ,日本,2003年 4月26日,Vol.205, No.4,p.278-279
REYNOLDS, B.A., et al.,Clonal and Population Analyses Demonstrate That an EGF-Responsisve Mammalian Embryonic CNS Precursor Is a Stem Cell,DEVELOPMENTAL BIOLOGY,1996年,Vol.175,p.1-13
SHINGO, T., et al.,Pregnancy-Stimulated neurogenesis in the Adult Female Forebrain mediated by Prolactin,SCIENCE,2003年 1月 3日,Vol.299,p.117-120
大多茂樹, 他.,神経幹細胞と神経ペプチド,日本内分泌学会雑誌,日本,2003年 9月20日,Vol.79, No.2,p.356
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Takuji Yamada
Mitsutaka Iwasaki