Title:
TRPC3、TRPC6及びTRPC7イオンチャネルの選択的阻害剤としてのノルゲスチメートの使用
Document Type and Number:
Japanese Patent JP2011500738
Kind Code:
A
Abstract:
TRPC ion channels are non-selective channels widely expressed in human tissues. These channels are involved in numerous physiological functions and are putative targets for the development of novel medicines. There is a need to gain a better understanding of TRPC ion channels in cells and beyond. The present invention provides a pharmacological tool compound that allows to study TRPC ion channels due to its discriminating inhibition of TRPC subfamilies. In the present invention, norgestimate is shown to selectively inhibit TRPC3, TRPC6 and TRPC7.
Inventors:
Zuzane Mie
Heinz-Werner Klemann
Tsarsten Strubbing
Heinz-Werner Klemann
Tsarsten Strubbing
Application Number:
JP2010530309A
Publication Date:
January 06, 2011
Filing Date:
October 14, 2008
Export Citation:
Assignee:
Sanofi-Aventis
International Classes:
A61K31/567; A61P9/00; A61P9/10; A61P13/12; A61P25/00; A61P25/04; A61P29/00; A61P43/00; C07J1/00
Domestic Patent References:
| JP2006508945A | 2006-03-16 |
Foreign References:
| US20030119796A1 | 2003-06-26 | |||
| US20010044584A1 | 2001-11-22 | |||
| WO2006102596A2 | 2006-09-28 |
Other References:
JPN7013003028; ＬＵＣＫＹ， Ａ． Ｗ． ｅｔ ａｌ: 'Ｅｆｆｅｃｔｉｖｅｎｅｓｓ ｏｆ ｎｏｒｇｅｓｔｉｍａｔｅ ａｎｄ ｅｔｈｉｎｙｌ ｅｓｔｒａｄｉｏｌ ｉｎ ｔｒｅａｔｉｎｇ ｍｏｄｅｒａｔｅ ａｃｎｅ ｖｕｌｇａｒｉｓ．' ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＡＭＥＲＩＣＡＮ ＡＣＡＤＥＭＹ ＯＦ ＤＥＲＭＡＴＯＬＯＧＹ Ｖｏｌ．３７， Ｎｏ．５， Ｐｔ．１, 1997, ｐ．７４６-７５４
JPN7013003029; ＹＬＩＫＯＲＫＡＬＡ， Ｏ． ｅｔ ａｌ: 'Ｅｆｆｅｃｔｓ ｏｎ ｓｅｒｕｍ ｌｉｐｉｄ ｐｒｏｆｉｌｅｓ ｏｆ ｃｏｎｔｉｎｕｏｕｓ １７ｂｅｔａ-ｅｓｔｒａｄｉｏｌ， ｉｎｔｅｒｍｉｔｔｅｎｔ ｎｏｒｇｅｓｔｉｍａｔｅ ｒｅｇｉｍｅｎｓ ｖ' ＣＬＩＮＩＣＡＬ ＴＨＥＲＡＰＥＵＴＩＣＳ Ｖｏｌ．２２， Ｎｏ．５, 2000, ｐ．６２２-６３６
JPN6013039864; ＯＬＳＯＮ， Ｗ． Ｈ． ｅｔ ａｌ: 'Ｔｈｅ ｄｕｒａｔｉｏｎ ｏｆ ｒｅｓｐｏｎｓｅ ｔｏ ｎｏｒｇｅｓｔｉｍａｔｅ ａｎｄ ｅｔｈｉｎｙｌ ｅｓｔｒａｄｉｏｌ ｉｎ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ａｃｎｅ ｖｕｌｇａｒｉｓ．' ＩＮＴＥＲＮＡＴＩＯＮＡＬ ＪＯＵＲＮＡＬ ＯＦ ＦＥＲＴＩＬＩＴＹ ＡＮＤ ＷＯＭＥＮ'Ｓ ＭＥＤＩＣＩＮＥ Ｖｏｌ．４３， Ｎｏ．６, 1998, ｐ．２８６-２９０
JPN6013039865; ＭＡＴＴＯＸ， Ｊ． Ｈ． ｅｔ ａｌ: 'Ｃｏｍｂｉｎｅｄ ｏｒａｌ ｈｏｒｍｏｎｅ ｒｅｐｌａｃｅｍｅｎｔ ｔｈｅｒａｐｙ ｆｏｒｍｕｌａｔｉｏｎｓ．' ＡＭＥＲＩＣＡＮ ＪＯＵＲＮＡＬ ＯＦ ＯＢＳＴＥＴＲＩＣＳ ＡＮＤ ＧＹＮＥＣＯＬＯＧＹ Ｖｏｌ．１８５， Ｎｏ．２, 2001, ｐ．Ｓ３８-Ｓ４６
JPN7013003029; ＹＬＩＫＯＲＫＡＬＡ， Ｏ． ｅｔ ａｌ: 'Ｅｆｆｅｃｔｓ ｏｎ ｓｅｒｕｍ ｌｉｐｉｄ ｐｒｏｆｉｌｅｓ ｏｆ ｃｏｎｔｉｎｕｏｕｓ １７ｂｅｔａ-ｅｓｔｒａｄｉｏｌ， ｉｎｔｅｒｍｉｔｔｅｎｔ ｎｏｒｇｅｓｔｉｍａｔｅ ｒｅｇｉｍｅｎｓ ｖ' ＣＬＩＮＩＣＡＬ ＴＨＥＲＡＰＥＵＴＩＣＳ Ｖｏｌ．２２， Ｎｏ．５, 2000, ｐ．６２２-６３６
JPN6013039864; ＯＬＳＯＮ， Ｗ． Ｈ． ｅｔ ａｌ: 'Ｔｈｅ ｄｕｒａｔｉｏｎ ｏｆ ｒｅｓｐｏｎｓｅ ｔｏ ｎｏｒｇｅｓｔｉｍａｔｅ ａｎｄ ｅｔｈｉｎｙｌ ｅｓｔｒａｄｉｏｌ ｉｎ ｔｈｅ ｔｒｅａｔｍｅｎｔ ｏｆ ａｃｎｅ ｖｕｌｇａｒｉｓ．' ＩＮＴＥＲＮＡＴＩＯＮＡＬ ＪＯＵＲＮＡＬ ＯＦ ＦＥＲＴＩＬＩＴＹ ＡＮＤ ＷＯＭＥＮ'Ｓ ＭＥＤＩＣＩＮＥ Ｖｏｌ．４３， Ｎｏ．６, 1998, ｐ．２８６-２９０
JPN6013039865; ＭＡＴＴＯＸ， Ｊ． Ｈ． ｅｔ ａｌ: 'Ｃｏｍｂｉｎｅｄ ｏｒａｌ ｈｏｒｍｏｎｅ ｒｅｐｌａｃｅｍｅｎｔ ｔｈｅｒａｐｙ ｆｏｒｍｕｌａｔｉｏｎｓ．' ＡＭＥＲＩＣＡＮ ＪＯＵＲＮＡＬ ＯＦ ＯＢＳＴＥＴＲＩＣＳ ＡＮＤ ＧＹＮＥＣＯＬＯＧＹ Ｖｏｌ．１８５， Ｎｏ．２, 2001, ｐ．Ｓ３８-Ｓ４６
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi