Title:
ブプレノルフィンのための出発物質としてのオリパビンの使用
Document Type and Number:
Japanese Patent JP2009522357
Kind Code:
A
Abstract:
There is provided a method for the synthesis of norbuprenorphine, and ultimately buprenorphine, utilizing oripavine as the starting material. Conventional methods of producing buprenorphine utilize thebaine as the starting material, requiring an O-demethylation step, typically a low to moderate yield transformation. The present use of oripavine as a starting material does not require an O-demethylation step, since the oripavine molecule lacks an O-3 methyl group.
Inventors:
Anthony Mannino
Eric Earl Hofgen
Lloyd Pee Hill
Henry Jay Buchler
Eric Earl Hofgen
Lloyd Pee Hill
Henry Jay Buchler
Application Number:
JP2008549488A
Publication Date:
June 11, 2009
Filing Date:
December 18, 2006
Export Citation:
Assignee:
Mallinckrodt INC.
International Classes:
C07D489/12; C07B61/00
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi
Takuji Yamada
Mitsutaka Iwasaki
Aoyama Aoi