Title:
置換酒石酸の誘導体及びβ-セクレターゼ阻害剤を調製するための使用
Document Type and Number:
Japanese Patent JP5314597
Kind Code:
B2
Abstract:
The present invention relates to compounds represented by formula (I), or isomers, prodrugs, pharmaceutically acceptable salts, solvates or hydrates thereof:
in which each substituent of formula (I) is as defined in the specification. The present invention also relates to preparation methods of compounds represented by formula (I), a pharmaceutical composition comprising compounds represented by formula (I) and usage of compounds represented by formula (I) for treating chronic neurodegenerative diseases such as Alzheimer's disease and other diseases induced by aggregation or deposition of ²-amyloid peptide.
Inventors:
Lee sung
Liao, Guo Chao
Xiao, Jun Hai
Nie, Aifa
One, lili
Tson, Wu
Zen, Zibin
Liao, Guo Chao
Xiao, Jun Hai
Nie, Aifa
One, lili
Tson, Wu
Zen, Zibin
Application Number:
JP2009543325A
Publication Date:
October 16, 2013
Filing Date:
February 05, 2007
Export Citation:
Assignee:
Institute of Pharmacology and Toxicology Academy of Military Medical Sciences PLA China
International Classes:
C07C235/12; A61K31/195; A61K31/197; A61K31/198; A61K31/216; A61K31/223; A61K31/24; A61K31/495; A61P25/00; A61P25/28; A61P43/00; C07C235/16; C07D295/10; C07B61/00
Domestic Patent References:
| JP2005520791A | ||||
| JP2005538162A | ||||
| JP2006282605A | ||||
| JP2002326995A | ||||
| JP2085227A | ||||
| JP3266819A | ||||
| JP2008513497A | ||||
| JP2007530583A | ||||
| JP2007516207A |
Foreign References:
| US20060178366 | ||||
| US2742500 | ||||
| WO2008031508A1 |
Other References:
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Synthesis,2001年,(16),2441-2444
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Australian Journal of Chemistry ,1987年,40(10),1723-35
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Macromolecules,1999年,32(24),8015-8023
Archives of Biochemistry and Biophysics ,1984年,228(2),627-38
Canadian Journal of Chemistry ,1968年,46(19),3091-4
Bioorganic and Medicinal Chemistry,2002年,10(5),1567-1580
Tetrahedron: Asymmetry ,1996年,7(4),1189-1198
Journal of Chromatography, A,1997年,757(1 + 2),73-79
Journal of Medicinal Chemistry,1971年,14(6),535-43
Journal of the American Chemical Society ,2003年,125(48),14733-14740
Synthesis,2001年,(16),2441-2444
Gazzetta Chimica Italiana,1917年,47(1),272-85
Journal of the Chemical Society ,1939,638-40
Australian Journal of Chemistry ,1987年,40(10),1723-35
Bulletin of the Institute for Chemical Research, Kyoto University,1985年,63(2),100-3
Macromolecules,1999年,32(24),8015-8023
Archives of Biochemistry and Biophysics ,1984年,228(2),627-38
Canadian Journal of Chemistry ,1968年,46(19),3091-4
Bioorganic and Medicinal Chemistry,2002年,10(5),1567-1580
Attorney, Agent or Firm:
Yuichi Yamada
Masakazu Noda
Ikeda adult
Masakazu Noda
Ikeda adult