Title:
Use of stem cells to reduce leukocyte overflow
Document Type and Number:
Japanese Patent JP6325419
Kind Code:
B2
Abstract:
The invention is generally directed to reducing inflammation by means of cells that secrete factors that reduce leukocyte extravasation. Specifically, the invention is directed to methods using cells that secrete factors that downregulate the expression of cellular adhesion molecules in vascular endothelial cells. Downregulating expression of cellular adhesion molecules reduces leukocyte adhesion to the endothelial cells such that extravasation is reduced. The end result is a reduction of inflammation. The cells are non-embryonic non-germ cells that have pluripotent characteristics. These may include expression of pluripotential markers and broad differentiation potential.
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Inventors:
Juliana Megan Woda
Water buntshof
Water buntshof
Application Number:
JP2014222204A
Publication Date:
May 16, 2018
Filing Date:
October 31, 2014
Export Citation:
Assignee:
ABT Holding Company
International Classes:
C12N5/071; A61K35/545; A61P29/00; A61P43/00; C12Q1/02; A61K35/12
Domestic Patent References:
| JP2009523846A |
Other References:
Blood(2009.Jul.16)Vol.114,No.3,p.693-701
Blood(2006)Vol.107,No.10,p.4182-4188
Cytotherapy(2007)Vol.9,No.5,p.477-487
Cytotherapy(2008)Vol.10,No.7,p.730-742
Cell.Immunol.(Epub 2008.Nov.20)Vol.255,No.1-2,p.55-60
Blood(2006)Vol.107,No.10,p.4182-4188
Cytotherapy(2007)Vol.9,No.5,p.477-487
Cytotherapy(2008)Vol.10,No.7,p.730-742
Cell.Immunol.(Epub 2008.Nov.20)Vol.255,No.1-2,p.55-60
Attorney, Agent or Firm:
Takeshi Oshio
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