Title:
良性及び/または悪性腫瘍の治療のためのステロイド誘導体の使用
Document Type and Number:
Japanese Patent JP2004524325
Kind Code:
A
Abstract:
The present invention relates to steroid derivatives for use as medicaments. More specifically, the invention also relates to the use of a steroid derivative of 5-androstene-, 5-pregnenolone or corresponding saturated derivatives (androstane- or pregnane-) in the manufacture of a medicament for the treatment of a benign and/or malignant tumour, which medicament is capable of interrupting disturbances in Wnt-signaling, such as cell-cycle arrest in G1-phase, and/or providing an angiostatic effect. Examples of such steroid derivatives are DELTA -5-androstene-17 alpha -ol, androstane-17 alpha -ol-pregnane-17 alpha -ol or pregnane-17 alpha -ol derivatives. In a further aspect, the invention relates to a method of producing a medicament for the treatment of a benign and/or malignant tumour and/or an inflammatory condition comprising the steps of contacting 5-androstane-3ss,17 alpha -diol or androstane-3ss alpha -diol, an enzyme and a sulfotransferase to provide 5-androstene-17 alpha -ol-3ss-sulfate or corresponding androstane derivative (17 alpha -AEDS or 17-AADS); and mixing the 17 alpha -AEDS or 17 alpha -AADS so produced with a suitable carrier; whereby a medicament which is capable of acting as a ligand to perox-isome proliferator-activated receptor- gamma (PPAR gamma ) is produced.
Inventors:
Thomas Hagstrom
Soderkvist, Peter
Buckval, Jean-Earling
Soderkvist, Peter
Buckval, Jean-Earling
Application Number:
JP2002570963A
Publication Date:
August 12, 2004
Filing Date:
March 11, 2002
Export Citation:
Assignee:
Thomas Hagstrom
International Classes:
A61K47/36; A61K31/37; A61K31/568; A61K31/569; A61K31/57; A61K45/06; A61P1/04; A61P19/02; A61P25/00; A61P27/02; A61P29/00; A61P35/00; A61P35/04; A61P37/02; A61P43/00; C07J1/00; C07J31/00; (IPC1-7): C07J1/00; A61K31/568; A61K47/36; A61P1/04; A61P19/02; A61P25/00; A61P27/02; A61P29/00; A61P35/00; A61P37/02; A61P43/00
Attorney, Agent or Firm:
Masaaki Ogura