Title:
結晶の差異評価への表面自由エネルギーの使用、表面自由エネルギーを指標として評価される結晶及び該結晶を含有してなる医薬組成物
Document Type and Number:
Japanese Patent JP5513660
Kind Code:
B2
Abstract:
An object is to provide means for suppressing the formation of any isomer of luliconazole on account of any influence of, for example, the humidity and the light and improving the stability. Disclosed is a method for differential evaluating a crystal of luliconazole, comprising differential evaluating the crystal by using, as indexes, surface free energy of the crystal of luliconazole and a ratio of a polar component of the surface free energy, wherein the crystal is evaluated to be stable on condition that the surface free energy is smaller and the ratio of the polar component is lower.
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Inventors:
Takaaki Masuda
Hideo Kaneda
Hideo Kaneda
Application Number:
JP2013098432A
Publication Date:
June 04, 2014
Filing Date:
May 08, 2013
Export Citation:
Assignee:
Pola Pharma Co., Ltd.
Nippon Pesticides Co., Ltd.
Nippon Pesticides Co., Ltd.
International Classes:
C07D409/06; A61K31/4178; A61P31/10; G01N13/00
Domestic Patent References:
| JP9100279A |
Other References:
JOURNAL OF PHARMACEUTICAL SCIENCES,(2002),91(2),P.571-583
LANGMUIR,(2006),22(16),P.6905-9
LANGMUIR,(2006),22(16),P.6905-9
Attorney, Agent or Firm:
Yoshiyuki Kawaguchi
Shinichi Sanuki
Takeshi Niwa
Toshiaki Shimoda
Shinichi Sanuki
Takeshi Niwa
Toshiaki Shimoda