Title:
神経学的疾患または障害を処置するためのＶＭＡＴ２阻害剤
Document Type and Number:
Japanese Patent JP7155206
Kind Code:
B2
Abstract:
Methods are provided herein for treating agitation in a subject who has Alzheimer's disease comprising administering a VMAT2 inhibitor to a subject in need thereof. VMAT2 inhibitors useful in the methods provided herein include tetrabenazine and (S)-2-Amino-3-methyl-butyric acid (2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-yl ester.
Inventors:
Christopher F. O'Brien
Dimitri E. Grigoli Adis
Dimitri E. Grigoli Adis
Application Number:
JP2020133607A
Publication Date:
October 18, 2022
Filing Date:
August 06, 2020
Export Citation:
Assignee:
Neurocline Biosciences, Inc.
International Classes:
A61K31/4375; A61K9/20; A61K9/48; A61K31/4745; A61K45/00; A61P21/00; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P43/00
Foreign References:
| WO2014047167A1 | ||||
| WO2008058261A1 |
Other References:
The Journal of Neuroscience,2013年,Vol.33, No.49,p.19120-19130
Expert Opinion on Investigational Drugs,Vol.24, No.6,2015年03月25日,p.737-742
Expert Opinion on Investigational Drugs,Vol.24, No.6,2015年03月25日,p.737-742
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Morishita Natsuki