Title:
VACCINE COMPOSITION FOR ELICITING IMMUNE RESPONSE AGAINST N-GLYCOLYLATED GANGLIOSIDE AND ITS USE FOR CANCER TREATMENT
Document Type and Number:
Japanese Patent JP3044173
Kind Code:
B2
Abstract:
PURPOSE: To obtain the subject composition containing an N-glycolylated ganglioside (derivative), as necessary, coupled to a specific carrier, the corresponding oligosaccharide and a proper adjuvant and useful for preventing and treating breast cancer.
CONSTITUTION: This composition contains an N-glycolylated ganglioside (derivative), as necessary, coupled by (non)covalent bonding to a carrier comprising a (conjugated)protein (e.g. a protein containing monoclonal antibody or a conjugated protein containing outer membrane of Neisseria meningitidis) [e.g. N- glucolyl GM3(NGcGM3)], the corresponding oligosaccharide (e.g. NGcGM3 oligosaccharide) and a proper adjuvant (e.g. monoclonal antibody such as P3 or an adjuvant comprising an aluminum salt and derived from natural).
Inventors:
Roland Perez Rodriguez
Louis Enrique Fernandez Molina
Guilda Marquina Rodriguez
Adriana Car Perez
Oscar Gonzalo Variente Hernandez
Louis Enrique Fernandez Molina
Guilda Marquina Rodriguez
Adriana Car Perez
Oscar Gonzalo Variente Hernandez
Application Number:
JP32866994A
Publication Date:
May 22, 2000
Filing Date:
December 28, 1994
Export Citation:
Assignee:
CENTRO DE INMUNOLOGIA MOLECULAR
International Classes:
C12P19/26; A61K31/70; A61K39/00; A61K39/385; A61K39/39; A61K47/48; A61P35/00; A61P37/04; C07H15/04; C07K16/30; C12R1/91; (IPC1-7): A61K39/00; A61K39/385; A61K39/39; A61P35/00; A61P37/04
Attorney, Agent or Firm:
Akira Asamura (3 outside)