Title:
ワクチン組成物
Document Type and Number:
Japanese Patent JP2006500963
Kind Code:
A
Abstract:
The present invention relates to the field of neisserial vaccine compositions, their manufacture, and the use of such compositions in medicine. More particularly it relates to processes of making novel engineered meningococcal strains which are more suitable for the production of neisserial, in particular meningococcal, outer-membrane vesicle (or bleb) vaccines. Advantageous processes and vaccine products are also described based on the use of novel LOS subunit or meningococcal outer-membrane vesicle (or bleb) vaccines which have been rendered safer and/or more effective for use in human subjects. In particular combinations of gene downregulations are described such as PorA & OpA, PorA and OpC, OpA and OpC, and PorA and OpA and OpC. The FrpB downregulation is also described. Alternatively, or in addition, IgtB - is shown to be an optimal mutation for effectively and safely using L3 and/or L2 LOS in Neisseria vaccine compositions. Bleb vaccines derived from IgtB - and capsular polysaccharide deficient meningococcal mutants are further described; as are advantageous methods of making bleb preparations where LOS is to be retained as an important antigen.
Inventors:
Beams, Ralph
Philip Denoel
Ferron, christiane
Goraz, Karine
Jennings, Michael, Paul
Poolman, Jean
Waynants, Vincent
Philip Denoel
Ferron, christiane
Goraz, Karine
Jennings, Michael, Paul
Poolman, Jean
Waynants, Vincent
Application Number:
JP2005506113A
Publication Date:
January 12, 2006
Filing Date:
July 31, 2003
Export Citation:
Assignee:
GlaxoSmithKline Biologicals Society Anonymous
The University of Queensland
The University of Queensland
International Classes:
C12N1/21; A61K39/095; A61K39/102; A61P31/04; A61P37/04; C07K14/22; C12N1/20; C12N15/09; C12P19/00; A61K39/00
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Ishii Teiji
Satoshi Fujita