Title:
組織メタロプロテイナーゼ阻害物質３型（ＴＩＭＰ－３）の変異体、組成物、及び方法
Document Type and Number:
Japanese Patent JP7075426
Kind Code:
B2
Abstract:
The application relates to variants or muteins of tissue inhibitor of metalloproteinase 3 (TIMP-3), especially variants thereof where certain amino acid residues are substituted in order to introduce N-linked glycosylation sites (N-X-T or N-X-S). Some of the variants made improve the half-life and pharmacokinetic or pharmacodynamic properties and facilitate production and purification. In particular, the mutein contain the pairs: K45N/V47T; K50N/V52T; P56N/G58T; H78N/Q80T; K94N/E96T; D110N/K112T; the substitutions R138T; G173T and, optionally, also F57N, leading to at least two engineered N-linked glycosylation sites.
Inventors:
O'Neill, Jason, Sea.
Ketchum, Randall, Earl.
Lee, Tae Won
Chintal Guts, Vishnu
Stevens, Genit, Lian
Ketchum, Randall, Earl.
Lee, Tae Won
Chintal Guts, Vishnu
Stevens, Genit, Lian
Application Number:
JP2020036642A
Publication Date:
May 25, 2022
Filing Date:
March 04, 2020
Export Citation:
Assignee:
Amjien Incorporated
International Classes:
C07K14/765; C07K14/81; C07K16/00; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/15; C12N15/63; C12P21/02
Foreign References:
| US20030143693 |
Attorney, Agent or Firm:
Hiraki International Patent Office
Yusuke Hiraki
Yusuke Hiraki