Title:
哺乳動物プロラクチンの変型体
Document Type and Number:
Japanese Patent JP4324477
Kind Code:
B2
Abstract:
The invention relates to mammal prolactin (PRL) variants having a mutation or set of mutations within the 14 N-terminal amino acids thereby preventing the formation of a disulfide bridge between Cys4 and Cys11, and a sterically hindering mutation or set of mutations within binding site 2 of PRL. These variants are useful as antagonists of mammal prolactin receptors (PRLR), more particularly of human prolactin receptor (hPRLR).
Inventors:
Vincent, Goffin
Bernictain, Sophie
Kelly, Paul, A.
Bernictain, Sophie
Kelly, Paul, A.
Application Number:
JP2003558043A
Publication Date:
September 02, 2009
Filing Date:
January 08, 2003
Export Citation:
Assignee:
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE(INSERM)
International Classes:
A01K67/027; C07K14/575; A61K38/22; A61K48/00; A61P7/00; A61P15/00; A61P19/02; A61P29/00; A61P35/00; A61P37/02; A61P43/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09
Other References:
S. BERNICHTEIN,ENDO 2000, ENDOCRINE SOCIETY 82ND ANNUAL MEETING,2000年 6月,P153
J. Biol. Chem.,1996年,vol. 271,16573-16579
J. Biol. Chem.,1999年,vol. 274,26033-26043
Clin. Cancer Res.,1999年,vol. 5,3583-3593
J. Biol. Chem.,1996年,vol. 271,16573-16579
J. Biol. Chem.,1999年,vol. 274,26033-26043
Clin. Cancer Res.,1999年,vol. 5,3583-3593
Attorney, Agent or Firm:
Shintaro Nogawa