Title:
血管コロニー形成細胞および非生着血管細胞
Document Type and Number:
Japanese Patent JP2011519576
Kind Code:
A
Abstract:
Methods of generating and expanding human hemangio-colony forming cells and non-engrafting hemangio cells in vitro and methods of expanding and using such cells are disclosed. The methods permit the production of large numbers of hemangio-colony forming cells, non-engrafting hemangio cells as well as derivative cells, such as hematopoietic and endothelial cells. The cells obtained by the methods disclosed may be used for a variety of research, clinical, and therapeutic applications. Human non-engrafting hemangio cells are a novel progenitor cell population that is related to but distinct from the hemangioblast and human hemangio-colony forming cells. The invention also provides compositions, preparations, and solutions comprising hemangio-colony forming cells, non-engrafting hemangio cells or cells differentiated therefrom. The compositions, preparations, and solutions include cryopreserved preparations and substantially purified preparations, as well as mixed compositions formulated in combination with related hemangioblast progenitor cell types that can engraft into the bone marrow.
Inventors:
Lanza, Robert
Lou, Si-Jean
Lou, Si-Jean
Application Number:
JP2011508644A
Publication Date:
July 14, 2011
Filing Date:
May 06, 2009
Export Citation:
Assignee:
Advanced Cell Technology, Incorporated
International Classes:
C12N5/074; A61K35/28; A61P7/00; A61P9/00; A61P9/10; C12N5/00; C12N5/071; C12N5/0789
Foreign References:
| WO2007095064A2 | 2007-08-23 | |||
| WO2007120811A2 | 2007-10-25 |
Other References:
JPN6013057601; Ｓｔｅｍ Ｃｅｌｌｓ Ｄｅｖ． Ｖｏｌ．１６， Ｎｏ．４, 200708, ｐ．５４７-５５９
JPN6013057603; Ｅｘｐ． Ｈｅｍａｔｏｌ． Ｖｏｌ．３２， Ｎｏ．１０, 200410, ｐ．１０００-１００９
JPN6013057599; Ｃｅｌｌ Ｖｏｌ．１３１， Ｎｏ．５, 20071130, ｐ．８６１-８７２
JPN6014034891; Ｎａｔｕｒｅ Ｖｏｌ．４５１， Ｎｏ．７１７５, 20080110, ｐ．１４１-１４６
JPN6014034894; Ｎａｔ． Ｂｉｏｔｅｃｈｎｏｌ． Ｖｏｌ．２６， Ｎｏ．１１, 200811, ｐ．１２６９-１２７５
JPN6013057603; Ｅｘｐ． Ｈｅｍａｔｏｌ． Ｖｏｌ．３２， Ｎｏ．１０, 200410, ｐ．１０００-１００９
JPN6013057599; Ｃｅｌｌ Ｖｏｌ．１３１， Ｎｏ．５, 20071130, ｐ．８６１-８７２
JPN6014034891; Ｎａｔｕｒｅ Ｖｏｌ．４５１， Ｎｏ．７１７５, 20080110, ｐ．１４１-１４６
JPN6014034894; Ｎａｔ． Ｂｉｏｔｅｃｈｎｏｌ． Ｖｏｌ．２６， Ｎｏ．１１, 200811, ｐ．１２６９-１２７５
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita