Title:
血管収縮性の置換アリールオキシアルキルジアミン類
Document Type and Number:
Japanese Patent JP3659969
Kind Code:
B2
Abstract:
PCT No. PCT/EP94/02702 Sec. 371 Date Feb. 5, 1996 Sec. 102(e) Date Feb. 5, 1996 PCT Filed Aug. 12, 1994 PCT Pub. No. WO95/05366 PCT Pub. Date Feb. 23, 1995The present invention is concerned with compounds having the formula (I) the pharmaceutically acceptable acid addition salts thereof, and the stereochemically isomeric forms thereof, wherein R1 is hydrogen or C1-6alkyl; R2 is hydrogen or C1-6alkyl; R3 is C1-6alkyl, hydroxy, cyano, halo, C1-6alkyloxy, aryloxy, arylmethoxy, C2-6alkenyl, C2-6alkynyl, C1-6alkyl-S-, C1-6alkyl(S=O)-, C1-6alkylcarbonyl; R4 is hydrogen, halo, hydroxy, C1-6alkyl, or C1-6alkyloxy; or R3 and R4 taken together form a bivalent radical; R5 and R6 each independently are hydrogen, halo, hydroxy, C1-6alkyl, C1-6alkyloxy, aryloxy or arylmethoxy; R7 is hydrogen; Alk1 is C2-5alkanediyl; Alk2 is C2-15alkanediyl; Q is a heterocyclic ring containing at least one nitrogen atom or a radical of formula (aa) Pharmaceutical compositions, preparations and use as a medicine are described.
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Inventors:
Van Lomen, Guy Rosalia Usien
De Bruin, Marcel France Leopold
Wiegerink, Piet Tom Belt Paul
De Bruin, Marcel France Leopold
Wiegerink, Piet Tom Belt Paul
Application Number:
JP50675195A
Publication Date:
June 15, 2005
Filing Date:
August 12, 1994
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
A61K31/17; A61K31/275; A61K31/41; A61K31/425; A61K31/426; A61K31/501; A61K31/505; C07D233/88; A61K31/506; A61P9/08; A61P25/04; A61P25/06; C07C279/12; C07C279/24; C07C279/28; C07C279/30; C07D237/20; C07D239/14; C07D239/42; C07D241/20; C07D277/20; C07D277/42; C07D319/18; C07D405/12; C07D409/12; C07D411/12; A61K; C07D; (IPC1-7): C07C279/28; A61K31/17; A61K31/275; A61K31/41; A61K31/505; C07C279/24; C07D233/88; C07D239/42
Domestic Patent References:
| JP6329645A | ||||
| JP5117243A |
Other References:
BENKERT,V.B. et al., ARZNEIMITTEL FORSCHUNG. DRUG RESEARCH, 1975年, Vol.25, No.9, p.1404-1408
Attorney, Agent or Firm:
Heikichi Odashima