Title:
血管収縮性置換ジヒドロピラノピリジン
Document Type and Number:
Japanese Patent JP3650398
Kind Code:
B2
Abstract:
PCT No. PCT/EP94/02700 Sec. 371 Date Jan. 24, 1996 Sec. 102(e) Date Jan. 24, 1996 PCT Filed Aug. 12, 1994 PCT Pub. No. WO95/05381 PCT Pub. Date Feb. 23, 1995The present invention is concerned with compounds of formula (I) the pharmaceutically acceptable acid addition salts thereof, the +E,uns N+EE -oxides thereof and the stereochemically isomeric forms thereof, wherein =a1-a2=a3-a4= is a bivalent radical of formula:=N-CH=CH-CH=(a),=CH-N=CH-CH=(b),=CH-CH=N-CH=(c),=CH-CH=CH-N=(d),wherein in said bivalent radicals one or two hydrogen atoms can be substituted by halo, hydroxy, C1-6alkyl or C1-6alkyloxy; R1 is hydrogen or C1-6alkyl; R2 is hydrogen or C1-6alkyl; R3 is hydrogen or C1-6alkyl; Alk1 is C1-5alkanediyl; Alk2 is C2-15alkanediyl; Q is a five- or six-membered heterocyclic ring containing at least one nitrogen atom or a radical of formula (aa) wherein R4 is hydrogen, cyano, aminocarbonyl or C1-6alkyl; R5 is hydrogen, C1-6alkyl, C3-6alkenyl or C3-6alkynyl; R6 is hydrogen or C1-6alkyl; or R5 and R6 taken together may form a bivalent radical of formula -(CH2)4- or -(CH2)5-. Pharmaceutical compositions, preparations and use as a medicine are described.
Inventors:
Van Lomen, Guy Rosalia Usien
Fernandez-Gadea, Francisco Javier
Andres-Gill, Jose Ignacio
Mate Sants-Balesteros, Maria Encarnacion
Fernandez-Gadea, Francisco Javier
Andres-Gill, Jose Ignacio
Mate Sants-Balesteros, Maria Encarnacion
Application Number:
JP50675095A
Publication Date:
May 18, 2005
Filing Date:
August 12, 1994
Export Citation:
Assignee:
JANSSEN PHARMACEUTICA NAAMLOZE VENNOOTSCHAP
International Classes:
A61K31/35; A61K31/436; A61K31/44; A61K31/453; A61K31/505; A61P9/02; A61P9/08; A61P25/04; A61P25/06; C07D405/12; C07D491/04; C07D491/052; (IPC1-7): C07D491/052; A61K31/44; A61K31/505; A61P9/02
Domestic Patent References:
| JP5202054A | ||||
| JP2096552A |
Attorney, Agent or Firm:
Heikichi Odashima