Title:
VASOPRESSIN ANTAGONISM
Document Type and Number:
Japanese Patent JPS63154699
Kind Code:
A
Abstract:
Compounds of the formula: in which: R is a group PA or AP; P is a D or L isomer of Tyr, MeTyr, O-alkyl Tyr, Trp, MeTrp, Val, MeVal, Phe, MePhe, Ile, MeIle, Leu, MeLeu, Sar, Ser or MeSer: A is a D or L isomer of Arg, Lys, HArg, MeArg, Orn, MeLys or MeHArg; B is OH, NH2 or NHAlk; Z is Phe, 4'-AlkPhe, O-AlkTyr, Ile or Tyr; X is a D or L isomer of Phe, 4'-AlkPhe, Val, Nva, Leu, Ile, Pba, Nle, Cha, Abu, Met, Chg, Tyr or O-AlkTyr; Y is Val, Ile, Abu, Ala, Chg, Gln, Lys, Cha, Nle, Thr, Phe, Leu or Gly; and R1 and R2 are, each, hydrogen, methyl, ethyl or, when taken together and with the beta -carbon to which they are attached, a cycloalkylene ring of 4 to 6 members; and wherein Alk is an alkyl group of 1 to 4 carbons; or pharmaceutically acceptable salts or prodrugs thereof, have activity as vasopressin antagonists.
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Inventors:
FUADEIA ERUFUEHAIRU ARI
Application Number:
JP30847787A
Publication Date:
June 27, 1988
Filing Date:
December 03, 1987
Export Citation:
Assignee:
SMITHKLINE BECKMAN CORP
International Classes:
A61K38/00; A61P1/16; A61P3/00; A61P7/00; A61P9/00; A61P9/02; C07K1/06; C07K1/113; C07K7/06; C07K7/16; C07K14/575; (IPC1-7): A61K37/02; C07K1/06; C07K7/06; C07K7/16; C07K99/00; C07K99/02
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)