Title:
VCAM-1に特異的に結合し、白血球と内皮細胞間の接合及び透過を阻害する組換えヒト単一クローン抗体
Document Type and Number:
Japanese Patent JP2013508356
Kind Code:
A
Abstract:
The present invention relates to a human recombinant monoclonal antibody that specifically binds to human Vascular Cell Adhesion Molecule-1 (VCAM-1) to inhibit adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, and a prophylactic and therapeutic composition for inflammatory disease or cancer comprising the same. The human recombinant monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human endothelial cell, and effectively inhibits VCAM-1-mediated adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, thereby being used for the prevention and treatment of inflammatory disease such as asthma and arthritis, transplant rejection, cardiovascular disease, and cancer.
Inventors:
Region
Moon Kyun Duk
Yung Ji Young
Sungbyung Je
Red Hong
Lee Dong Eun
Ryuyoung
Sim Hyunbo
Kang Kyung Jae
Moon Kyun Duk
Yung Ji Young
Sungbyung Je
Red Hong
Lee Dong Eun
Ryuyoung
Sim Hyunbo
Kang Kyung Jae
Application Number:
JP2012535139A
Publication Date:
March 07, 2013
Filing Date:
October 22, 2010
Export Citation:
Assignee:
Hanwha Chemical Corporation
International Classes:
C07K16/18; A61K39/395; A61P1/04; A61P3/06; A61P3/10; A61P9/00; A61P9/06; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P17/06; A61P19/02; A61P19/06; A61P25/00; A61P27/02; A61P29/00; A61P31/04; A61P31/10; A61P33/06; A61P35/00; A61P37/00; A61P37/06; G01N33/53; G01N33/574; C12N15/09; C12P21/08
Domestic Patent References:
| JP2009536641A | 2009-10-15 |
Other References:
JPN6013026091; Ｊ．Ｍｏｌ．Ｂｉｏｌ．，２００８ Ｆｅｂ ２９，３７６（４），ｐ．１１８２-２００
JPN6013026092; Ｊ．Ｂｉｏｌ．Ｃｈｅｍ．，２００３ Ｏｃｔ ３，２７８（４０），ｐ．３８１９４-２０５
JPN6013026092; Ｊ．Ｂｉｏｌ．Ｃｈｅｍ．，２００３ Ｏｃｔ ３，２７８（４０），ｐ．３８１９４-２０５
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Kazumi Nakamura
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Kazumi Nakamura