Title:
VEGF-BINDING FUSION PEPTIDE
Document Type and Number:
Japanese Patent JP2014047156
Kind Code:
A
Abstract:
To provide an antibody-like substance not having an immunoglobulin structure, which can inhibit the binding or interaction between VEGF and VEFGR.
VEGF-binding fusion protein is a VEGF-binding peptide having a helix-loop-helix structure which comprises A block being a peptide forming α-helix structure and located at N-terminal, C block being a peptide forming α-helix structure and located at C-terminal, and B block being a peptide connecting A block and C block with covalent bonding, where thioredoxin is attached to the N-terminal of the A block, and the B block is a peptide having a specified amino acid sequence. The VEGF-binding fusion peptide inhibits cell proliferation.
Inventors:
FUJII IKUO
Application Number:
JP2012190551A
Publication Date:
March 17, 2014
Filing Date:
August 30, 2012
Export Citation:
Assignee:
UNIV OSAKA PREFECTURE
International Classes:
C07K19/00; A61K38/00; A61P27/02; A61P29/00; A61P35/00; A61P43/00; C07K16/24; C12N15/09
Domestic Patent References:
| JP2011231085A | 2011-11-17 | |||
| JP2008214254A | 2008-09-18 | |||
| JP2005154382A | 2005-06-16 | |||
| JP2005151921A | 2005-06-16 | |||
| JP2005151921A | 2005-06-16 | |||
| JP2011231085A | 2011-11-17 | |||
| JP2008214254A | 2008-09-18 | |||
| JP2005154382A | 2005-06-16 |
Foreign References:
| WO2011071279A2 | 2011-06-16 | |||
| WO2011071279A2 | 2011-06-16 |
Other References:
JPN6016020320; Ｄｒｕｇ Ｄｅｌｉｖｅｒｙ Ｓｙｓｔｅｍ Ｖｏｌ．２６， Ｎｏ．６, 2011, ｐ．５９３-６０３
JPN6016020320; Ｄｒｕｇ Ｄｅｌｉｖｅｒｙ Ｓｙｓｔｅｍ Ｖｏｌ．２６， Ｎｏ．６, 2011, ｐ．５９３-６０３
JPN6016020320; Ｄｒｕｇ Ｄｅｌｉｖｅｒｙ Ｓｙｓｔｅｍ Ｖｏｌ．２６， Ｎｏ．６, 2011, ｐ．５９３-６０３
Attorney, Agent or Firm:
Naoji Shimura
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