Title:
VEHICLES FOR CONTROLLED DELIVERY OF DIFFERENT PHARMACEUTICAL AGENTS
Document Type and Number:
Japanese Patent JP2021138771
Kind Code:
A
Abstract:
To provide vehicles for controlled delivery of different pharmaceutical agents.SOLUTION: A "nanolipogel" is a delivery vehicle including one or more lipid layer surrounding a hydrogel core, which may include an absorbent such as a cyclodextrin or ion-exchange resin. Nanolipogels can be constructed so as to incorporate a variety of different chemical entities that can subsequently be released in a controlled fashion. These different incorporated chemical entities can differ dramatically with respect to size and composition. Nanolipogels have been constructed to contain co-encapsulated proteins as well as small hydrophobic drugs within the interior of the lipid bilayer. Agents incorporated within nanolipogels can be released into the milieu in a controlled fashion, for example, nanolipogels provide a means of achieving simultaneous sustained release of agents that differ widely in chemical composition and molecular weight. Additionally, nanolipogels can favorably modulate biodistribution.SELECTED DRAWING: None
Inventors:
TAREK M FAHMY
ERIC STERN
RICHARD A FLAVELL
JASON PARK
ALYSSA SIEFERT
STEPHEN H WRZESINSKI
ERIC STERN
RICHARD A FLAVELL
JASON PARK
ALYSSA SIEFERT
STEPHEN H WRZESINSKI
Application Number:
JP2021101463A
Publication Date:
September 16, 2021
Filing Date:
June 18, 2021
Export Citation:
Assignee:
UNIV YALE
International Classes:
A61K9/127; A61K9/06; A61K9/51; A61K47/04; A61K47/18; A61K47/24; A61K47/28; A61K47/32; A61K47/34; A61K47/38; A61K47/40; A61K47/42
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita