PURPOSE: To obtain a viable bacterium preparation containing a viable bacteri um and chlorella powder as an excipient, useful for medicines, foods, etc., and capable of enhancing the survival rate of bacterial cells after prepared.
CONSTITUTION: The viable bacterium preparation contains a viable bacterium, preferably lactobacillus, as a main ingredient and 60-90wt.% of chlorella powder as an excipient. The chlorella powder has following properties; a particle degree distribution: particle sizes of ≤149μm: 80-98%, particle sizes of 150-250μm: 2-20%; a bulk density of 0.37±0.05; a tap density: 0.46±0.05g/cm3; and an angle of repose: 42±5 degree. The addition of a conventional binder such as crystalline cellulose, calcium carboxymethylcellulose or α-starch to the chlorella in an amount of 3-20wt.% gives tablets high in hardness without killing the viable lactobacillus. If necessary, a lubricant, a perfume, a pigment, a pharmacodynamic ingredient, etc., may be added to prepare a formulation. The tabletting enables to prevent abrasion and defects generated on storage or carriage.
ANDO YOTARO
SHINPO KUNIHIRO
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