Title:
VINCINIC ACID DERIVATIVE AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPS5436297
Kind Code:
A
Abstract:
Vincinic acid derivatives of the general formula (I): wherein R represents hydrogen or an alkyl group containing from 2 to 6 carbon atoms, optionally substituted with hydroxyl, R1 represents hydroxyl, R2 represents hydrogen, or if R does not represent hydrogen, R1 and R2 together may form a valence bond between two adjacent carbon atoms, and acid addition salts and quaternary salts thereof, especially the esters thereof, show valuable vasodilating activity and may be used as active ingredients of pharmaceutical compositions. The compounds are prepared by hydrolysis of vincine to vincinic acid, optionally followed by esterification and/or dehydration and/or salt formation.
Inventors:
RORINTSUE TSUSABA
KARUMAN SASU
RASURO SUPORUNI
EGON KARUPATEI
KARUMAN SASU
RASURO SUPORUNI
EGON KARUPATEI
Application Number:
JP9104278A
Publication Date:
March 16, 1979
Filing Date:
July 27, 1978
Export Citation:
Assignee:
RICHTER GEDEON VEGYESZET
International Classes:
A61K31/435; A61K31/4375; C07D519/04; A61K31/475; A61P9/08; C07D461/00; (IPC1-7): A61K31/435; C07D471/22
Foreign References:
| DE2458164A1 | 1975-06-26 |