Title:
ウィルス複製のインヒビター
Document Type and Number:
Japanese Patent JP2009513576
Kind Code:
A
Abstract:
The embodiments provide compounds of the general Formulas I-IV, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
Inventors:
Leonid Biegelmann
Stephen W Andrews
Kevin Earl Kondoloski
Indrani Gunawaradana
Julia Haas
Stephen W Andrews
Kevin Earl Kondoloski
Indrani Gunawaradana
Julia Haas
Application Number:
JP2008535577A
Publication Date:
April 02, 2009
Filing Date:
October 10, 2006
Export Citation:
Assignee:
InterMune Incorporated
International Classes:
C07C237/20; A61K31/165; A61K31/167; A61K31/196; A61K31/197; A61K31/215; A61K31/245; A61K31/40; A61K31/4035; A61K31/417; A61K31/4178; A61K31/4188; A61K31/437; A61K31/445; A61K31/4453; A61K31/454; A61K31/495; A61K31/496; A61K31/5375; A61P31/14; A61P43/00; C07C323/62; C07D207/09; C07D209/44; C07D211/58; C07D211/62; C07D233/61; C07D295/12; C07D295/18; C07D307/68; C07D409/04; C07D409/14; C07D471/04; C07D487/04
Domestic Patent References:
| JPH06502639A | 1994-03-24 | |||
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| JP2005510476A | 2005-04-21 | |||
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| JP2008506702A | 2008-03-06 | |||
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| JPS5052242A | 1975-05-09 | |||
| JPS45024776B1 |
Foreign References:
| US3668217A | 1972-06-06 | |||
| FR1389841A | 1965-02-19 | |||
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| US3389146A | 1968-06-18 |
Other References:
MARINTCHEV, ASSEN; MIRTCHEVA, JASMINA; SIDJIMOV, ATANAS; HAIMOVE, MARIETA: "Induction of lymphoproliferative popliteal lymph node reaction by hydantoin derivatives: structu", INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, vol. 17(12), JPN6012021213, 1995, pages 981 - 4, ISSN: 0002208642
DE ROSA, MICHAEL; MELENSKI, EDWARD; HOLDER, ANDREW J.: "Reaction of 1-methylpyrrole with 1,3-dichloro-5,5-disubstituted hydantoins: products and AM1 stu", HETEROCYCLES, vol. 36(5), JPN7012001537, 1993, pages 1059 - 64, ISSN: 0002208641
DE ROSA, MICHAEL; MELENSKI, EDWARD; HOLDER, ANDREW J.: "Reaction of 1-methylpyrrole with 1,3-dichloro-5,5-disubstituted hydantoins: products and AM1 stu", HETEROCYCLES, vol. 36(5), JPN7012001537, 1993, pages 1059 - 64, ISSN: 0002208641
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro