Title:
ビタミンB12誘導体及びそれらの製造方法
Document Type and Number:
Japanese Patent JP4794735
Kind Code:
B2
Abstract:
This invention relates to methods for preparing vitamin B12 (VB12) derivatives suitable for linking to a polymer, nanoparticle or therapeutic agent, protein or peptide. The methods involve reacting the 5'OH group of VB12 or an analogue thereof with an active carbonyl electrophile and subsequently obtaining said VB12 derivatives. The invention also relates to novel VB12 derivatives, VB12 derivatives prepared by the methods of the present invention and uses thereof in the preparation of in the preparation of polymer complexes or nanoparticles.
Inventors:
Russell-Jones Greg
McIwan John
McIwan John
Application Number:
JP2000554755A
Publication Date:
October 19, 2011
Filing Date:
June 11, 1999
Export Citation:
Assignee:
Bio-APTY Limited
International Classes:
A61K9/51; C07H23/00; A61K31/7135; A61K31/714; A61K47/48
Domestic Patent References:
| JPH05180773A | 1993-07-23 | |||
| JPS54157600A | 1979-12-12 | |||
| JPH06336494A | 1994-12-06 | |||
| JPS62103064A | 1987-05-13 | |||
| JPH1077257A | 1998-03-24 |
Foreign References:
| WO1997014740A1 | 1997-04-24 | |||
| WO1998047870A1 | 1998-10-29 |
Attorney, Agent or Firm:
Shohei Oguri
Hironori Honda
Toshimitsu Ichikawa
Hironori Honda
Toshimitsu Ichikawa