Title:
ビタミンＤ３誘導体及びその薬学的用途
Document Type and Number:
Japanese Patent JP6784963
Kind Code:
B2
Abstract:
The present invention relates to vitamin D3 derivatives of the following formula, wherein each symbol has the same meaning as defined herein, and pharmaceutical or medical use thereof for treating metabolic disease, liver disease, obesity, diabetes, cardiovascular disease, or cancer in a patient in need thereof.
Inventors:
Mizuki Watanabe
Risa Asano
Kazuo Nagasawa
Uesugi Shigenari
Risa Asano
Kazuo Nagasawa
Uesugi Shigenari
Application Number:
JP2017534365A
Publication Date:
November 18, 2020
Filing Date:
December 24, 2015
Export Citation:
Assignee:
Kyoto University
National University Corporation Tokyo University of Agriculture and Technology
National University Corporation Tokyo University of Agriculture and Technology
International Classes:
C07C401/00; A61K31/593; A61P1/16; A61P3/00; A61P3/04; A61P3/10; A61P9/00; A61P35/00; A61P43/00; C07D209/48; C07D495/04
Domestic Patent References:
| JP60064924A |
Other References:
OVES, D. et al.,The Journal of Organic Chemistry,2003年,Vol. 68,pp. 1154-1157
OVES, D. et al.,Bioorganic & Medicinal Chemistry,2006年,Vol. 14,pp. 928-937
GLEBOCKA, A. et al.,Archives of Biochemistry and Biophysics,2012年,Vol. 523,pp48-57
SHIMAZAKI, M. et al.,Bioorganic & Medicinal Chemistry,2006年,Vol. 14,pp. 4645-4656
MICHALAK, K. et al.,The Journal of Organic Chemistry,2011年,Vol. 76,pp. 6906-6911
MARCZAK, S. et al.,Bioorganic & Medicinal Chemistry Letters,2001年,Vol. 11,pp. 63-66
FUJISHIMA, T. et al.,Bioorganic & Medicinal Chemistry,2000年,Vol. 8,pp. 123-134
WANG, X. X. et al.,American Journal of Physiology Renal Physiology,2011年,Vol. 300,pp. F801-F810
領田 優太、他,日本薬学会第133年会 予稿集,公益社団法人日本薬学会,2013年,29K-pm09S
OVES, D. et al.,Bioorganic & Medicinal Chemistry,2006年,Vol. 14,pp. 928-937
GLEBOCKA, A. et al.,Archives of Biochemistry and Biophysics,2012年,Vol. 523,pp48-57
SHIMAZAKI, M. et al.,Bioorganic & Medicinal Chemistry,2006年,Vol. 14,pp. 4645-4656
MICHALAK, K. et al.,The Journal of Organic Chemistry,2011年,Vol. 76,pp. 6906-6911
MARCZAK, S. et al.,Bioorganic & Medicinal Chemistry Letters,2001年,Vol. 11,pp. 63-66
FUJISHIMA, T. et al.,Bioorganic & Medicinal Chemistry,2000年,Vol. 8,pp. 123-134
WANG, X. X. et al.,American Journal of Physiology Renal Physiology,2011年,Vol. 300,pp. F801-F810
領田 優太、他,日本薬学会第133年会 予稿集,公益社団法人日本薬学会,2013年,29K-pm09S
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toyotaka Abe
Taku Yamada
Makoto Shiraishi
Toyotaka Abe
Taku Yamada
Makoto Shiraishi