p27/Kip1遺伝子の5’上流に存在するビタミンD3応答配列、および該配列を利用した薬剤のスクリーニング方法

Japanese Patent JP4828070

B2

A 44-bp region that confers vitamin D3-responsiveness to the human p27Kip1 promoter in the human p27Kip1 transcriptional regulatory mechanism was revealed. This region also conferred vitamin D3-responsiveness to a heterogenous promoter. Moreover, it was found that vitamin D3 enhances the binding between the CCAAT box existing in the region and the NF-Y protein and also the binding between the Sp1 sequence (also existing in the region) and the Sp1 protein, thus inducing human p27Kip1 transcription. Also revealed were methods of screening for pharmaceutical agents that regulate the expression of the p27Kip1 gene using these molecular mechanisms.

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Toshiyuki Sakai

JP2001553943A

November 30, 2011

July 21, 2000

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Chugai Pharmaceutical Co., Ltd.
Toshiyuki Sakai

C12N15/09; A61K31/593; A61P35/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/65; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50

JPH11137251A

1999-05-25

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto

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